N-<1-glycyl>trans-3-<4-<1-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-2-<<(phenylmethoxy)carbonyl>amino>-ethyl>phenoxy>-L-prolyl>-L-isoleucine

Base Information

Chemical Name:N-<1-glycyl>trans-3-<4-<1-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-2-<<(phenylmethoxy)carbonyl>amino>-ethyl>phenoxy>-L-prolyl>-L-isoleucine
CAS No.:129575-04-8
Molecular Formula:C₄₀H₆₀N₄O₁₀Si
Molecular Weight:785.023
Hs Code.:

N-<1-<N-<(1,1-dimethylethoxy)carbonyl>glycyl>trans-3-<4-<1-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-2-<<(phenylmethoxy)carbonyl>amino>-ethyl>phenoxy>-L-prolyl>-L-isoleucine

Synonyms:N-<1-glycyl>trans-3-<4-<1-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-2-<<(phenylmethoxy)carbonyl>amino>-ethyl>phenoxy>-L-prolyl>-L-isoleucine

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Chemical Property of N-<1-glycyl>trans-3-<4-<1-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-2-<<(phenylmethoxy)carbonyl>amino>-ethyl>phenoxy>-L-prolyl>-L-isoleucine

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Technology Process of N-<1-glycyl>trans-3-<4-<1-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-2-<<(phenylmethoxy)carbonyl>amino>-ethyl>phenoxy>-L-prolyl>-L-isoleucine

There total 7 articles about N-<1-glycyl>trans-3-<4-<1-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-2-<<(phenylmethoxy)carbonyl>amino>-ethyl>phenoxy>-L-prolyl>-L-isoleucine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.7%

: 129575-03-7
N-<1-glycyl>trans-3-<4-<1-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-2-<<(phenylmethoxy)carbonyl>amino>ethyl>phenoxy>-L-prolyl>-L-isoleucine methyl ester

: 129575-04-8
N-<1-glycyl>trans-3-<4-<1-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-2-<<(phenylmethoxy)carbonyl>amino>-ethyl>phenoxy>-L-prolyl>-L-isoleucine

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; 1.) 0 deg C, 9 h, 2.) RT, 45 min;

Reference yield:

: 123043-38-9,123043-39-0
N-trans-3-(4-cyanophenoxy)-1-glycyl>-L-prolyl-L-isoleucine methyl ester

: 129575-04-8
N-<1-glycyl>trans-3-<4-<1-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-2-<<(phenylmethoxy)carbonyl>amino>-ethyl>phenoxy>-L-prolyl>-L-isoleucine

Guidance literature:: Multi-step reaction with 6 steps

1: 76.4 percent / Raney Ni, NaH₂PO₂*H₂O, buffer 2:1:1 pyridine: acetic acid: water / 4 h / 55 - 60 °C

2: 93.6 percent / sodium methoxide / 3.5 h / 0 °C

3: 94.8 percent / imidazole / dimethylformamide / 1.) 0 deg C, 30 min, 2.) RT, 9.5 h

4: 87.8 percent / ammonium formate / Pd/C / methanol / 7.5 h / Ambient temperature

5: 95 percent / Et₃N / tetrahydrofuran; H₂O / 5 h / 0 °C

6: 79.7 percent / aq. 0.5 M lithium hydroxide / tetrahydrofuran / 1.) 0 deg C, 9 h, 2.) RT, 45 min

With 1H-imidazole; lithium hydroxide; sodium hypophosphite; buffer 2:1:1 pyridine: acetic acid: water; sodium methylate; ammonium formate; nickel; triethylamine; isobutyric Acid; palladium on activated charcoal; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;

Reference yield:

: 129574-99-8
N-<1-glycyl>-trans-3-<4-(formylphenoxy)-L-prolyl>-L-isoleucine methyl ester

: 129575-04-8
N-<1-glycyl>trans-3-<4-<1-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-2-<<(phenylmethoxy)carbonyl>amino>-ethyl>phenoxy>-L-prolyl>-L-isoleucine

Guidance literature:: Multi-step reaction with 5 steps

1: 93.6 percent / sodium methoxide / 3.5 h / 0 °C

2: 94.8 percent / imidazole / dimethylformamide / 1.) 0 deg C, 30 min, 2.) RT, 9.5 h

3: 87.8 percent / ammonium formate / Pd/C / methanol / 7.5 h / Ambient temperature

4: 95 percent / Et₃N / tetrahydrofuran; H₂O / 5 h / 0 °C

5: 79.7 percent / aq. 0.5 M lithium hydroxide / tetrahydrofuran / 1.) 0 deg C, 9 h, 2.) RT, 45 min

With 1H-imidazole; lithium hydroxide; sodium methylate; ammonium formate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;