(5-((R)-2-hydroxypropyl)-2-methoxyphenyl)((S)-2-(methoxymethyl)pyrrolidin-1-yl)methanone

Base Information

Chemical Name:(5-((R)-2-hydroxypropyl)-2-methoxyphenyl)((S)-2-(methoxymethyl)pyrrolidin-1-yl)methanone
CAS No.:928118-82-5
Molecular Formula:C₁₇H₂₅NO₄
Molecular Weight:307.39
Hs Code.:

Synonyms:(5-((R)-2-hydroxypropyl)-2-methoxyphenyl)((S)-2-(methoxymethyl)pyrrolidin-1-yl)methanone

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Chemical Property of (5-((R)-2-hydroxypropyl)-2-methoxyphenyl)((S)-2-(methoxymethyl)pyrrolidin-1-yl)methanone

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Technology Process of (5-((R)-2-hydroxypropyl)-2-methoxyphenyl)((S)-2-(methoxymethyl)pyrrolidin-1-yl)methanone

There total 1 articles about (5-((R)-2-hydroxypropyl)-2-methoxyphenyl)((S)-2-(methoxymethyl)pyrrolidin-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 911847-39-7
(S)-(5-iodo-2-methoxyphenyl)(2-(methoxymethyl)pyrrolidin-1-yl)methanone

: 15448-47-2
(R)-propylene oxide

: 928118-82-5
(5-((R)-2-hydroxypropyl)-2-methoxyphenyl)((S)-2-(methoxymethyl)pyrrolidin-1-yl)methanone

Guidance literature:: (S)-(5-iodo-2-methoxyphenyl)(2-(methoxymethyl)pyrrolidin-1-yl)methanone; With isopropylmagnesium chloride; In tetrahydrofuran; at 20 ℃; for 1h;

(R)-propylene oxide; With copper(I) bromide; In tetrahydrofuran; at 0 ℃;
DOI:10.1021/jo0621423

Reference yield: 57.0%

: 928118-82-5
(5-((R)-2-hydroxypropyl)-2-methoxyphenyl)((S)-2-(methoxymethyl)pyrrolidin-1-yl)methanone

: 106-95-6
allyl bromide

: 928119-04-4
((R)-1-allyl-5-((R)-2-(allyloxy)propyl)-2-methoxycyclohexa-2,5-dienyl)((S)-2-(methoxymethyl)-pyrrolidin-1-yl)methanone

: ((S)-1-allyl-5-((R)-2-(allyloxy)propyl)-2-methoxycyclohexa-2,5-dienyl)((S)-2-(methoxymethyl)-pyrrolidin-1-yl)methanone

Guidance literature:: (5-((R)-2-hydroxypropyl)-2-methoxyphenyl)((S)-2-(methoxymethyl)pyrrolidin-1-yl)methanone; With ammonia; potassium; In tetrahydrofuran; at -78 ℃; for 0.333333h;

allyl bromide; In tetrahydrofuran; at -78 - 20 ℃;
DOI:10.1021/jo0621423

Reference yield:

: 928118-82-5
(5-((R)-2-hydroxypropyl)-2-methoxyphenyl)((S)-2-(methoxymethyl)pyrrolidin-1-yl)methanone

: 928119-18-0
(R)-2-allyl-4-((R)-2-(allyloxy)propyl)-2-((S)-2-(methoxymethyl)pyrrolidine-1-carbonyl)cyclohex-3-enone

Guidance literature:: Multi-step reaction with 2 steps

1.1: liq. NH₃; potassium / tetrahydrofuran / 0.33 h / -78 °C

1.2: 57 percent / tetrahydrofuran / -78 - 20 °C

2.1: 94 percent / HCl / methanol / 15 h / 20 °C

With hydrogenchloride; ammonia; potassium; In tetrahydrofuran; methanol; 1.1: Birch reduction;
DOI:10.1021/jo0621423