tert-butyl (2S,3S,5S)-1-amino-5-(benzyloxymethyl)-2-hydroxy-6-methylheptan-3-ylcarbamate

Base Information

Chemical Name:tert-butyl (2S,3S,5S)-1-amino-5-(benzyloxymethyl)-2-hydroxy-6-methylheptan-3-ylcarbamate
CAS No.:953820-34-3
Molecular Formula:C₂₁H₃₆N₂O₄
Molecular Weight:380.528
Hs Code.:

Synonyms:tert-butyl (2S,3S,5S)-1-amino-5-(benzyloxymethyl)-2-hydroxy-6-methylheptan-3-ylcarbamate

Suppliers and Price of tert-butyl (2S,3S,5S)-1-amino-5-(benzyloxymethyl)-2-hydroxy-6-methylheptan-3-ylcarbamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl (2S,3S,5S)-1-amino-5-(benzyloxymethyl)-2-hydroxy-6-methylheptan-3-ylcarbamate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of tert-butyl (2S,3S,5S)-1-amino-5-(benzyloxymethyl)-2-hydroxy-6-methylheptan-3-ylcarbamate

There total 12 articles about tert-butyl (2S,3S,5S)-1-amino-5-(benzyloxymethyl)-2-hydroxy-6-methylheptan-3-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.3%

: 953820-33-2
tert-butyl (1S,3S)-3-(benzyloxymethyl)-4-methyl-1-((R)-oxiran-2-yl)pentylcarbamate

: 953820-34-3
tert-butyl (2S,3S,5S)-1-amino-5-(benzyloxymethyl)-2-hydroxy-6-methylheptan-3-ylcarbamate

Guidance literature:: With methanol; ammonia; water; at 20 ℃; for 18h;

Reference yield:

: 365541-75-9
(2R)-3-methyl-2-[(phenylmethoxy)methyl]butan-1-ol

: 953820-34-3
tert-butyl (2S,3S,5S)-1-amino-5-(benzyloxymethyl)-2-hydroxy-6-methylheptan-3-ylcarbamate

Guidance literature:: Multi-step reaction with 8 steps

1.1: N-Bromosuccinimide; triphenylphosphine / dichloromethane / 18 h / 0 - 20 °C

2.1: n-butyllithium / tetrahydrofuran; hexanes / 1.25 h / -78 °C

2.2: 20.5 h / -78 - -20 °C

3.1: hydrogenchloride; water / acetonitrile / 1.5 h / 20 °C

3.2: 0 °C

4.1: triethylamine / dichloromethane / 20 h / 0 - 20 °C

5.1: sodium tetrahydroborate / ethanol / 16 h / 20 °C

6.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1.75 h / -60 - -50 °C

7.1: sodium hydride / dimethyl sulfoxide / 1 h / 20 °C

7.2: 1 h / 20 °C

8.1: methanol; ammonia; water / 18 h / 20 °C

With hydrogenchloride; methanol; sodium tetrahydroborate; N-Bromosuccinimide; n-butyllithium; oxalyl dichloride; ammonia; water; sodium hydride; dimethyl sulfoxide; triethylamine; triphenylphosphine; In tetrahydrofuran; hexanes; ethanol; dichloromethane; dimethyl sulfoxide; acetonitrile; 6.1: Swern Oxidation;

Reference yield:

: 861451-15-2
tert-butyl (3(S)-benzyloxymethyl-1(S)-hydroxymethyl-4-methyl-pentyl)carbamate

: 953820-34-3
tert-butyl (2S,3S,5S)-1-amino-5-(benzyloxymethyl)-2-hydroxy-6-methylheptan-3-ylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1.75 h / -60 - -50 °C

2.1: sodium hydride / dimethyl sulfoxide / 1 h / 20 °C

2.2: 1 h / 20 °C

3.1: methanol; ammonia; water / 18 h / 20 °C

With methanol; oxalyl dichloride; ammonia; water; sodium hydride; dimethyl sulfoxide; In dichloromethane; dimethyl sulfoxide; 1.1: Swern Oxidation;