(S)-1-[2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-benzoyl]-piperidine-2-carboxylic acid

Base Information

• Chemical Name: (S)-1-[2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-benzoyl]-piperidine-2-carboxylic acid
• CAS No.: 361379-82-0
• Molecular Formula: C₂₁H₁₈N₂O₅
• Molecular Weight: 378.384

Synonyms:(S)-1-[2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-benzoyl]-piperidine-2-carboxylic acid

Chemical Property of (S)-1-[2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-benzoyl]-piperidine-2-carboxylic acid

Chemical Property:

Purity/Quality:

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Technology Process of (S)-1-[2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-benzoyl]-piperidine-2-carboxylic acid

There total 4 articles about (S)-1-[2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-benzoyl]-piperidine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

(S)-1-[2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-benzoyl]-piperidine-2-carboxylic acid benzyl ester (361379-65-9) → (S)-1-[2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-benzoyl]-piperidine-2-carboxylic acid (361379-82-0)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 18h;

DOI:10.1055/s-2001-15060

Reference yield:

phthalic anhydride (85-44-9) → (S)-1-[2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-benzoyl]-piperidine-2-carboxylic acid (361379-82-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 140 °C

2: 41 percent / 1-hydroxybenzotriazol; Et₃N; dicyclohexylcarbodiimide / dimethylformamide

3: 64 percent / H₂ / 10 percent Pd/C / methanol / 18 h / 20 °C

With hydrogen; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

DOI:10.1055/s-2001-15060

Reference yield:

2-phthalimidobenzoic acid (41513-78-4) → (S)-1-[2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-benzoyl]-piperidine-2-carboxylic acid (361379-82-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 41 percent / 1-hydroxybenzotriazol; Et₃N; dicyclohexylcarbodiimide / dimethylformamide

2: 64 percent / H₂ / 10 percent Pd/C / methanol / 18 h / 20 °C

With hydrogen; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

DOI:10.1055/s-2001-15060

upstream raw materials:

(S)-1-[2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-benzoyl]-piperidine-2-carboxylic acid benzyl ester

phthalic anhydride

2-phthalimidobenzoic acid

anthranilic acid

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