(2-benzyl-6-fluoro-1-thioxo-1,2,3,4-tetrahydro-β-carbolin-9-yl)acetic acid t-butyl ester

Base Information

Chemical Name:(2-benzyl-6-fluoro-1-thioxo-1,2,3,4-tetrahydro-β-carbolin-9-yl)acetic acid t-butyl ester
CAS No.:1161933-44-3
Molecular Formula:C₂₄H₂₅FN₂O₂S
Molecular Weight:424.539
Hs Code.:

Synonyms:(2-benzyl-6-fluoro-1-thioxo-1,2,3,4-tetrahydro-β-carbolin-9-yl)acetic acid t-butyl ester

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Chemical Property of (2-benzyl-6-fluoro-1-thioxo-1,2,3,4-tetrahydro-β-carbolin-9-yl)acetic acid t-butyl ester

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Technology Process of (2-benzyl-6-fluoro-1-thioxo-1,2,3,4-tetrahydro-β-carbolin-9-yl)acetic acid t-butyl ester

There total 6 articles about (2-benzyl-6-fluoro-1-thioxo-1,2,3,4-tetrahydro-β-carbolin-9-yl)acetic acid t-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 5292-43-3
bromoacetic acid tert-butyl ester

: 1161933-43-2
2-benzyl-6-fluoro-2,3,4,9-tetrahydro-β-carboline-1-thione

: 1161933-44-3
(2-benzyl-6-fluoro-1-thioxo-1,2,3,4-tetrahydro-β-carbolin-9-yl)acetic acid t-butyl ester

Guidance literature:: 2-benzyl-6-fluoro-2,3,4,9-tetrahydro-β-carboline-1-thione; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 0.5h; Cooling with ice;

bromoacetic acid tert-butyl ester; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃;

Reference yield:

: 110977-72-5
C₉H₁₂O₅

: 1161933-44-3
(2-benzyl-6-fluoro-1-thioxo-1,2,3,4-tetrahydro-β-carbolin-9-yl)acetic acid t-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide / water

2.1: 220 °C

3.1: Lawessons reagent / toluene / Reflux

4.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

4.2: 0 - 20 °C

With Lawessons reagent; sodium hydride; sodium hydroxide; In water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmc.2011.10.073

Reference yield:

: 20893-71-4
4-fluorophenyldiazonium chloride

: 1161933-44-3
(2-benzyl-6-fluoro-1-thioxo-1,2,3,4-tetrahydro-β-carbolin-9-yl)acetic acid t-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide / water

2.1: 220 °C

3.1: Lawessons reagent / toluene / Reflux

4.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

4.2: 0 - 20 °C

With Lawessons reagent; sodium hydride; sodium hydroxide; In water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmc.2011.10.073