4-(2-chloro-4-fluorophenyl)-5-[(2,4-difluorophenyl)fluoromethyl]-1,3-dimethyl-1H-pyrazole

Base Information

Chemical Name:4-(2-chloro-4-fluorophenyl)-5-[(2,4-difluorophenyl)fluoromethyl]-1,3-dimethyl-1H-pyrazole
CAS No.:1358582-67-8
Molecular Formula:C₁₈H₁₃ClF₄N₂
Molecular Weight:368.761
Hs Code.:

Synonyms:4-(2-chloro-4-fluorophenyl)-5-[(2,4-difluorophenyl)fluoromethyl]-1,3-dimethyl-1H-pyrazole

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Chemical Property of 4-(2-chloro-4-fluorophenyl)-5-[(2,4-difluorophenyl)fluoromethyl]-1,3-dimethyl-1H-pyrazole

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Technology Process of 4-(2-chloro-4-fluorophenyl)-5-[(2,4-difluorophenyl)fluoromethyl]-1,3-dimethyl-1H-pyrazole

There total 5 articles about 4-(2-chloro-4-fluorophenyl)-5-[(2,4-difluorophenyl)fluoromethyl]-1,3-dimethyl-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1242019-44-8
4-(2-chloro-4-fluorophenyl)-α-(2,4-difluorophenyl)-1,3-dimethyl-1H-pyrazole-5-methanol

: 1358582-67-8
4-(2-chloro-4-fluorophenyl)-5-[(2,4-difluorophenyl)fluoromethyl]-1,3-dimethyl-1H-pyrazole

Guidance literature:: With diethylamino-sulfur trifluoride; In dichloromethane; at 20 ℃; for 1h; Cooling with ice; Inert atmosphere;

Reference yield:

: 75279-56-0
2-(2-chloro-4-fluorophenyl)acetonitrile

: 1358582-67-8
4-(2-chloro-4-fluorophenyl)-5-[(2,4-difluorophenyl)fluoromethyl]-1,3-dimethyl-1H-pyrazole

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium ethanolate / ethanol; xylene / 4 h / 50 °C

2.1: sodium acetate / ethanol / 16 h / Reflux

3.1: copper(ll) bromide; tert.-butylnitrite / acetonitrile / 20 °C / Cooling with ice

4.1: n-butyllithium / cyclohexane; tetrahydrofuran / 0.33 h / Cooling with acetone-dry ice; Inert atmosphere

4.2: 0.75 h / Cooling

5.1: diethylamino-sulfur trifluoride / dichloromethane / 1 h / 20 °C / Cooling with ice; Inert atmosphere

With n-butyllithium; tert.-butylnitrite; diethylamino-sulfur trifluoride; sodium ethanolate; sodium acetate; copper(ll) bromide; In tetrahydrofuran; ethanol; dichloromethane; cyclohexane; acetonitrile; xylene; 3.1: Sandmeyer Reaction;

Reference yield:

: 1193511-96-4
4-(2-chloro-4-fluorophenyl)-1,3-dimethyl-1H-pyrazol-5-amine

: 1358582-67-8
4-(2-chloro-4-fluorophenyl)-5-[(2,4-difluorophenyl)fluoromethyl]-1,3-dimethyl-1H-pyrazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: copper(ll) bromide; tert.-butylnitrite / acetonitrile / 20 °C / Cooling with ice

2.1: n-butyllithium / cyclohexane; tetrahydrofuran / 0.33 h / Cooling with acetone-dry ice; Inert atmosphere

2.2: 0.75 h / Cooling

3.1: diethylamino-sulfur trifluoride / dichloromethane / 1 h / 20 °C / Cooling with ice; Inert atmosphere

With n-butyllithium; tert.-butylnitrite; diethylamino-sulfur trifluoride; copper(ll) bromide; In tetrahydrofuran; dichloromethane; cyclohexane; acetonitrile; 1.1: Sandmeyer Reaction;