1-(3,5-bis(trifluoromethyl)benzyl)-2-(nitromethylene)-imidazolidine

Base Information

• Chemical Name: 1-(3,5-bis(trifluoromethyl)benzyl)-2-(nitromethylene)-imidazolidine
• CAS No.: 1353880-47-3
• Molecular Formula: C₁₃H₁₁F₆N₃O₂
• Molecular Weight: 355.24
• Mol file: 1353880-47-3.mol

Synonyms:1-(3,5-bis(trifluoromethyl)benzyl)-2-(nitromethylene)-imidazolidine

Chemical Property of 1-(3,5-bis(trifluoromethyl)benzyl)-2-(nitromethylene)-imidazolidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(3,5-bis(trifluoromethyl)benzyl)-2-(nitromethylene)-imidazolidine

There total 1 articles about 1-(3,5-bis(trifluoromethyl)benzyl)-2-(nitromethylene)-imidazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

2-(nitromethylene)imidazolidine (13623-98-8) + 3,5-bis(trifluoromethyl)benzyl chloride (75462-59-8) → 1-(3,5-bis(trifluoromethyl)benzyl)-2-(nitromethylene)-imidazolidine (1353880-47-3)

Guidance literature:

2-(nitromethylene)imidazolidine; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 5 ℃; for 0.666667h;

3,5-bis(trifluoromethyl)benzyl chloride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃;

DOI:10.1021/jm201364d

Reference yield:

1-(3,5-bis(trifluoromethyl)benzyl)-2-(nitromethylene)-imidazolidine (1353880-47-3) → 1-(3,5-bis(trifluoromethyl)benzyl)-4,5-dihydro-1H-imidazole-2-carbaldehyde oxime (1353940-88-1)

Guidance literature:

With tin(II) chloride dihdyrate; In dichloromethane; at 20 ℃;

DOI:10.1021/jm201364d

Reference yield:

1-(3,5-bis(trifluoromethyl)benzyl)-2-(nitromethylene)-imidazolidine (1353880-47-3) → 1-(3,5-bis(trifluoromethyl)benzyl)-4,5-dihydro-1H-imidazole-2-carbaldehyde oxime hydrochloride (1353880-53-1)

Guidance literature:

Multi-step reaction with 2 steps

1: tin(II) chloride dihdyrate / dichloromethane / 20 °C

2: hydrogenchloride / methanol; diethyl ether; dichloromethane

With hydrogenchloride; tin(II) chloride dihdyrate; In methanol; diethyl ether; dichloromethane;

DOI:10.1021/jm201364d

upstream raw materials:

2-(nitromethylene)imidazolidine

3,5-bis(trifluoromethyl)benzyl chloride

Downstream raw materials:

1-(3,5-bis(trifluoromethyl)benzyl)-4,5-dihydro-1H-imidazole-2-carbaldehyde oxime

1-(3,5-bis(trifluoromethyl)benzyl)-4,5-dihydro-1H-imidazole-2-carbaldehyde oxime hydrochloride