trifluoromethanesulfonic acid 3,5-dichloro-2-trimethylsilanyl-phenyl ester

Base Information

• Chemical Name: trifluoromethanesulfonic acid 3,5-dichloro-2-trimethylsilanyl-phenyl ester
• CAS No.: 1242069-28-8
• Molecular Formula: C₁₀H₁₁Cl₂F₃O₃SSi
• Molecular Weight: 367.248
• Mol file: 1242069-28-8.mol

Synonyms:trifluoromethanesulfonic acid 3,5-dichloro-2-trimethylsilanyl-phenyl ester

Chemical Property of trifluoromethanesulfonic acid 3,5-dichloro-2-trimethylsilanyl-phenyl ester

Chemical Property:

Purity/Quality:

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Technology Process of trifluoromethanesulfonic acid 3,5-dichloro-2-trimethylsilanyl-phenyl ester

There total 4 articles about trifluoromethanesulfonic acid 3,5-dichloro-2-trimethylsilanyl-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

trifluoromethylsulfonic anhydride (358-23-6) + 3,5-dichloro-2-trimethylsilanyl-phenol (1242069-50-6) → trifluoromethanesulfonic acid 3,5-dichloro-2-trimethylsilanyl-phenyl ester (1242069-28-8)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at -40 ℃; for 5h; Inert atmosphere;

DOI:10.1021/acs.joc.0c01669

Reference yield:

3,5-dichloro-2(H)-pyran-2-one (22682-13-9) + trifluoromethylsulfonic anhydride (358-23-6) + 4,4,5,5-tetramethyl-2-trimethylsilanylethynyl-[1,3,2]dioxaborolane (159087-46-4) → trifluoromethanesulfonic acid 2,4-dichloro-6-trimethylsilanyl-phenyl ester (1242069-29-9) + trifluoromethanesulfonic acid 3,5-dichloro-2-trimethylsilanyl-phenyl ester (1242069-28-8)

Guidance literature:

3,5-dichloro-2(H)-pyran-2-one; 4,4,5,5-tetramethyl-2-trimethylsilanylethynyl-[1,3,2]dioxaborolane; In 1,3,5-trimethyl-benzene; at 155 ℃; for 16h; Inert atmosphere;

With dihydrogen peroxide; sodium carbonate; In ethanol; at 20 ℃;

trifluoromethylsulfonic anhydride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1039/c0cc01345e

Reference yield:

C9H12Cl2OSi → trifluoromethanesulfonic acid 3,5-dichloro-2-trimethylsilanyl-phenyl ester (1242069-28-8)

Guidance literature:

Multi-step reaction with 2 steps

1: bis(2,2,6,6-tetramethylpiperidin-1-yl)magnesium-bis(lithium chloride) complex / tetrahydrofuran / 4 h / -80 - 0 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 5 h / -40 °C / Inert atmosphere

With bis(2,2,6,6-tetramethylpiperidin-1-yl)magnesium-bis(lithium chloride) complex; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1021/acs.joc.0c01669

upstream raw materials:

3,5-dichloro-2(H)-pyran-2-one

trifluoromethylsulfonic anhydride

4,4,5,5-tetramethyl-2-trimethylsilanylethynyl-[1,3,2]dioxaborolane

3,5-dichlorophenol