ethyl 7-{[3-(2-trimethylsilylethynyl)phenyl]amino}pyrrolo[1,2-a]quinoxaline-4-carboxylate

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Chemical Name:ethyl 7-{[3-(2-trimethylsilylethynyl)phenyl]amino}pyrrolo[1,2-a]quinoxaline-4-carboxylate
CAS No.:1448531-74-5
Molecular Formula:C₂₅H₂₅N₃O₂Si
Molecular Weight:427.578
Hs Code.:

Synonyms:ethyl 7-{[3-(2-trimethylsilylethynyl)phenyl]amino}pyrrolo[1,2-a]quinoxaline-4-carboxylate

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Chemical Property of ethyl 7-{[3-(2-trimethylsilylethynyl)phenyl]amino}pyrrolo[1,2-a]quinoxaline-4-carboxylate

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Technology Process of ethyl 7-{[3-(2-trimethylsilylethynyl)phenyl]amino}pyrrolo[1,2-a]quinoxaline-4-carboxylate

There total 5 articles about ethyl 7-{[3-(2-trimethylsilylethynyl)phenyl]amino}pyrrolo[1,2-a]quinoxaline-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.0%

: 1448531-78-9
ethyl 4-bromopyrrolo[1,2-a]quinoxaline-4-carboxylate

: 110598-30-6
1-amino,3-trimethylsilylethynylbenzene

: 1448531-74-5
ethyl 7-{[3-(2-trimethylsilylethynyl)phenyl]amino}pyrrolo[1,2-a]quinoxaline-4-carboxylate

Guidance literature:: With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; at 100 ℃; for 20h;
DOI:10.1016/j.ejmech.2013.04.051

Reference yield:

: 1169610-77-8
1-(4-bromo-2-nitrophenyl)-1H-pyrrole

: 1448531-74-5
ethyl 7-{[3-(2-trimethylsilylethynyl)phenyl]amino}pyrrolo[1,2-a]quinoxaline-4-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: copper(II) sulfate; sodium tetrahydroborate / water / 1 h / 0 - 20 °C

2: triethylamine / tetrahydrofuran / 14 h / 0 - 20 °C

3: trichlorophosphate / 0.33 h / Reflux

4: caesium carbonate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 20 h / 100 °C

With sodium tetrahydroborate; palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; copper(II) sulfate; triethylamine; trichlorophosphate; In tetrahydrofuran; water; toluene;
DOI:10.1016/j.ejmech.2013.04.051

Reference yield:

: 896429-82-6
5-bromo-2-(1H-pyrrol-1-yl)aniline

: 1448531-74-5
ethyl 7-{[3-(2-trimethylsilylethynyl)phenyl]amino}pyrrolo[1,2-a]quinoxaline-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / tetrahydrofuran / 14 h / 0 - 20 °C

2: trichlorophosphate / 0.33 h / Reflux

3: caesium carbonate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 20 h / 100 °C

With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine; trichlorophosphate; In tetrahydrofuran; toluene;
DOI:10.1016/j.ejmech.2013.04.051