methyl (S)-2-[(S)-2-(tert-butoxycarbonylamino)-N-methyl-3-phenylpropanamido]-4-methylpentanoate

Base Information

Chemical Name:methyl (S)-2-[(S)-2-(tert-butoxycarbonylamino)-N-methyl-3-phenylpropanamido]-4-methylpentanoate
CAS No.:1357008-65-1
Molecular Formula:C₂₂H₃₄N₂O₅
Molecular Weight:406.522
Hs Code.:

Synonyms:methyl (S)-2-[(S)-2-(tert-butoxycarbonylamino)-N-methyl-3-phenylpropanamido]-4-methylpentanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl (S)-2-[(S)-2-(tert-butoxycarbonylamino)-N-methyl-3-phenylpropanamido]-4-methylpentanoate

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Technology Process of methyl (S)-2-[(S)-2-(tert-butoxycarbonylamino)-N-methyl-3-phenylpropanamido]-4-methylpentanoate

There total 3 articles about methyl (S)-2-[(S)-2-(tert-butoxycarbonylamino)-N-methyl-3-phenylpropanamido]-4-methylpentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 35026-08-5
N-methyl-L-leucine methyl ester

: 1357008-65-1
methyl (S)-2-[(S)-2-(tert-butoxycarbonylamino)-N-methyl-3-phenylpropanamido]-4-methylpentanoate

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 1.5h; Inert atmosphere;
DOI:10.1016/j.tet.2011.11.089

Reference yield:

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 3339-45-5
H-L-N-MeLeu-OMe*HCl

: 1357008-65-1
methyl (S)-2-[(S)-2-(tert-butoxycarbonylamino)-N-methyl-3-phenylpropanamido]-4-methylpentanoate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 0 - 20 ℃; for 24h; Inert atmosphere;
DOI:10.1016/j.molstruc.2016.03.019

Reference yield:

: 3060-46-6
N-methyl-L-leucine

: 1357008-65-1
methyl (S)-2-[(S)-2-(tert-butoxycarbonylamino)-N-methyl-3-phenylpropanamido]-4-methylpentanoate

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / 20 °C

2: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / dichloromethane / 20 °C

With thionyl chloride; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane;
DOI:10.1021/cn4000583