(+)-fortamine dihydrochloride

Base Information

Chemical Name:(+)-fortamine dihydrochloride
CAS No.:72351-21-4
Molecular Formula:C₈H₁₈N₂O₄*2ClH
Molecular Weight:279.164
Hs Code.:

Synonyms:(+)-fortamine dihydrochloride

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Chemical Property of (+)-fortamine dihydrochloride

Chemical Property:

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Technology Process of (+)-fortamine dihydrochloride

There total 50 articles about (+)-fortamine dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 111515-80-1
methyl (1R,2R,4S,5R,6R)-4-azido-5-hydroxy-9-methyl-8-oxo-9-aza-7-oxabicyclo<4.3.0>nonanecarboxylate

: 72351-21-4
(+)-fortamine dihydrochloride

Guidance literature:: Multi-step reaction with 10 steps

1: H₂ / Pd/C

2: NaHCO₃

3: 92 percent / imidazole

4: NaOH

5: 1.) 1-oxa-2-oxo-3-thia-indolizinium chloride, DMAP, CBrCl₃, 2.) DBU

6: NaH

7: OsO₄, trimethylamine N-oxide

8: 95 percent / NaH

9: n-Bu₄NF

10: 1.) 6N HCl, 2.) H₂ / 2.) Pd black

With 1H-imidazole; hydrogenchloride; dmap; sodium hydroxide; osmium(VIII) oxide; Bromotrichloromethane; trimethylamine-N-oxide; 1-oxa-2-oxo-3-thiaindolizinium chloride; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; sodium hydrogencarbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; palladium on activated charcoal; palladium;
DOI:10.1246/cl.1987.29

Reference yield:

: 111535-89-8
methyl (1R,2R,4R,5R,6S)-4,5-epoxy-9-methyl-8-oxo-9-aza-7-oxabicyclo<4.3.0>nonanecarboxylate

: 72351-21-4
(+)-fortamine dihydrochloride

Guidance literature:: Multi-step reaction with 11 steps

1: TMSN₃, ZnCl₂

2: H₂ / Pd/C

3: NaHCO₃

4: 92 percent / imidazole

5: NaOH

6: 1.) 1-oxa-2-oxo-3-thia-indolizinium chloride, DMAP, CBrCl₃, 2.) DBU

7: NaH

8: OsO₄, trimethylamine N-oxide

9: 95 percent / NaH

10: n-Bu₄NF

11: 1.) 6N HCl, 2.) H₂ / 2.) Pd black

With 1H-imidazole; hydrogenchloride; dmap; sodium hydroxide; osmium(VIII) oxide; Bromotrichloromethane; trimethylamine-N-oxide; trimethylsilylazide; 1-oxa-2-oxo-3-thiaindolizinium chloride; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; sodium hydrogencarbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; zinc(II) chloride; palladium on activated charcoal; palladium;
DOI:10.1246/cl.1987.29

Reference yield:

: 111515-81-2
methyl (1R,2R,4S,5R,6R)-4-<(benzyloxycarbonyl)amino>-5-hydroxy-9-methyl-8-oxo-9-aza-7-oxabicyclo<4.3.0>nonanecarboxylate

: 72351-21-4
(+)-fortamine dihydrochloride

Guidance literature:: Multi-step reaction with 8 steps

1: 92 percent / imidazole

2: NaOH

3: 1.) 1-oxa-2-oxo-3-thia-indolizinium chloride, DMAP, CBrCl₃, 2.) DBU

4: NaH

5: OsO₄, trimethylamine N-oxide

6: 95 percent / NaH

7: n-Bu₄NF

8: 1.) 6N HCl, 2.) H₂ / 2.) Pd black

With 1H-imidazole; hydrogenchloride; dmap; sodium hydroxide; osmium(VIII) oxide; Bromotrichloromethane; trimethylamine-N-oxide; 1-oxa-2-oxo-3-thiaindolizinium chloride; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; palladium;
DOI:10.1246/cl.1987.29