butyl (E)-3-(2-p-tolyl-1H-indol-3-yl)propenoate

Base Information

Chemical Name:butyl (E)-3-(2-p-tolyl-1H-indol-3-yl)propenoate
CAS No.:1258511-05-5
Molecular Formula:C₂₂H₂₃NO₂
Molecular Weight:333.43
Hs Code.:

Synonyms:butyl (E)-3-(2-p-tolyl-1H-indol-3-yl)propenoate

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Chemical Property of butyl (E)-3-(2-p-tolyl-1H-indol-3-yl)propenoate

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Technology Process of butyl (E)-3-(2-p-tolyl-1H-indol-3-yl)propenoate

There total 6 articles about butyl (E)-3-(2-p-tolyl-1H-indol-3-yl)propenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 141-32-2,9003-49-0
acrylic acid n-butyl ester

: 124643-45-4
2-(p-tolylethynyl)aniline

: 1258511-05-5
butyl (E)-3-(2-p-tolyl-1H-indol-3-yl)propenoate

Guidance literature:: With potassium iodide; palladium dichloride; In N,N-dimethyl-formamide; at 100 ℃; for 20h; regioselective reaction; in air;
DOI:10.1002/chem.201001535

Reference yield: 80.0%

: 141-32-2,9003-49-0
acrylic acid n-butyl ester

: 124643-45-4
2-(p-tolylethynyl)aniline

: 55577-25-8
2-(4-methylphenyl)-1H-indole

: 1258511-05-5
butyl (E)-3-(2-p-tolyl-1H-indol-3-yl)propenoate

Guidance literature:: With potassium iodide; palladium dichloride; In N,N-dimethyl-formamide; at 100 ℃; for 20h;
DOI:10.1002/chem.201001535

Reference yield:

: 615-43-0
2-iodophenylamine

: 766-97-2
4-n-methylphenylacetylene

: 1258511-05-5
butyl (E)-3-(2-p-tolyl-1H-indol-3-yl)propenoate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triphenylphosphine / N,N-dimethyl-formamide / 1.5 h / 50 °C / Inert atmosphere

2: triethylamine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triphenylphosphine / N,N-dimethyl-formamide / 3 h / 50 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; triphenylphosphine; In N,N-dimethyl-formamide; 1: |Sonogashira Cross-Coupling;
DOI:10.1055/s-0033-1338873