Carbamic acid, (2,5-dioxo-3-pyrrolidinyl)-, phenylmethyl ester (9CI)

Base Information

• Chemical Name: Carbamic acid, (2,5-dioxo-3-pyrrolidinyl)-, phenylmethyl ester (9CI)
• CAS No.: 84767-67-9
• Molecular Formula: C12H12 N2 O4
• Molecular Weight: 248.23468
• Hs Code.: 2925190090
• Mol file: 84767-67-9.mol

Synonyms:3-Pyrrolidinecarbamicacid, 2,5-dioxo-, benzyl ester (6CI,7CI)

Chemical Property of Carbamic acid, (2,5-dioxo-3-pyrrolidinyl)-, phenylmethyl ester (9CI)

Chemical Property:

• PSA: 91.48000
• LogP: 0.80820

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Carbamic acid, (2,5-dioxo-3-pyrrolidinyl)-, phenylmethyl ester (9CI)

There total 3 articles about Carbamic acid, (2,5-dioxo-3-pyrrolidinyl)-, phenylmethyl ester (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2,5-dioxopyrrolidin-3-aminium 2,2,2-trifluoroacetate + benzyl chloroformate (501-53-1,94274-21-2) → 3-[(benzyloxy)carbonylamino]pyrrolidine-2,5-dione (84767-67-9)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 0 ℃; for 2h; Reflux;

DOI:10.1021/acs.jmedchem.9b00454

Reference yield: 77.0%

N-benzyloxy-carbonyl-DL-asparagine (29880-22-6) → 3-[(benzyloxy)carbonylamino]pyrrolidine-2,5-dione (84767-67-9)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 5h;

DOI:10.1016/j.farmac.2004.01.004

Reference yield:

→ 3-[(benzyloxy)carbonylamino]pyrrolidine-2,5-dione (84767-67-9)

Guidance literature:

Asparaginsaeureester I (Z-Asn-OPFP);

DOI:10.1021/ja00852a048

upstream raw materials:

N-benzyloxy-carbonyl-DL-asparagine

benzyl chloroformate

Downstream raw materials:

1-methyl-3-[(benzyloxy)carbonylamino]pyrrolidine-2,5-dione

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