1-BROMO-4-(2,2-DIFLUOROVINYL)BENZENE

Base Information

• Chemical Name: 1-BROMO-4-(2,2-DIFLUOROVINYL)BENZENE
• CAS No.: 84750-93-6
• Molecular Formula: C8H5 Br F2
• Molecular Weight: 219.029
• Hs Code.: 2903999090
• Mol file: 84750-93-6.mol

Synonyms:2-(4-BROMOPHENYL)-1,1-DIFLUOROETHYLENE;1-BROMO-4-(2,2-DIFLUOROVINYL)BENZENE;4-BROMO-BETA,BETA-DIFLUOROSTYRENE

Chemical Property of 1-BROMO-4-(2,2-DIFLUOROVINYL)BENZENE

Chemical Property:

• Vapor Pressure: 0.287mmHg at 25°C
• Refractive Index: 1.557
• Boiling Point: 209.8°C at 760 mmHg
• Flash Point: 80.7°C
• PSA: 0.00000
• Density: 1.57
• LogP: 3.68650
• Storage Temp.: Freezer

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Bromo-β,β-difluorostyrene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-BROMO-4-(2,2-DIFLUOROVINYL)BENZENE

There total 26 articles about 1-BROMO-4-(2,2-DIFLUOROVINYL)BENZENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-bromo-benzaldehyde (1122-91-4) + 2,2‐difluoro‐2‐(triphenylphosphonio)acetate → 1,1-difluoro-2-(4-bromophenyl)ethene (84750-93-6)

Guidance literature:

In 1-methyl-pyrrolidin-2-one; at 60 ℃; for 1h; Sealed tube;

Reference yield: 90.0%

potassium 2-pyridinyl sulfonyl-difluoroacetate (1600503-70-5) + 4-bromo-benzaldehyde (1122-91-4) → 1,1-difluoro-2-(4-bromophenyl)ethene (84750-93-6)

Guidance literature:

potassium 2-pyridinyl sulfonyl-difluoroacetate; 4-bromo-benzaldehyde; In N,N-dimethyl-formamide; at 40 ℃; for 2h;

With hydrogenchloride; ammonium chloride; In N,N-dimethyl-formamide; at 40 ℃; for 2h; Temperature; Solvent;

DOI:10.1002/ejoc.201301654

Reference yield: 88.0%

(1-(4-bromophenyl)-2,2,2-trifluoroethyl)dimethyl(phenyl)silane → 1,1-difluoro-2-(4-bromophenyl)ethene (84750-93-6)

Guidance literature:

With tetrabutyl ammonium fluoride; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1021/acs.joc.1c01724

upstream raw materials:

chlorodifluoroacetic acid lithium salt

4-bromo-benzaldehyde

dibromodifluoromethane

hydrazone of p-bromobenzaldehyde

Downstream raw materials:

2-(4-bromobenzyl)quinoline

4,4'-((2RS,3SR)-1,1,1,4,4,4-hexafluorobutane-2,3-diyl)bis(bromobenzene)

Refernces

• 1、 Zhang, Jun-Qi,Hu, Dandan,Song, Jinyu,Ren, Hongjun. "-Annulation of gem-Difluoroalkenes and Pyridinium Ylides: Access to Functionalized 2-Fluoroindolizines". . p. 4646 - 4660. Retrieved 2021/04/06.
• 2、 Sorrentino, Jacob P.,Orsi, Douglas L.,Altman, Ryan A.. "Acid-Catalyzed Hydrothiolation of gem-Difluorostyrenes to Access α,α-Difluoroalkylthioethers". . p. 2297 - 2311. Retrieved 2021/02/06.