[(S)-1-((S)-2-{5-[4-(6-{3-[(S)-1-((S)-2-methoxycarbonylamino-3-methyl-butyryl)-pyrrolidine-2-carbonyl]-ureido}-benzothiazol-2-yl)-phenyl]-1H-imidazol-2-yl}-pyrrolidine-1-carbonyl)-2-methyl-propyl]-carbamic acid methyl ester

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Chemical Name:[(S)-1-((S)-2-{5-[4-(6-{3-[(S)-1-((S)-2-methoxycarbonylamino-3-methyl-butyryl)-pyrrolidine-2-carbonyl]-ureido}-benzothiazol-2-yl)-phenyl]-1H-imidazol-2-yl}-pyrrolidine-1-carbonyl)-2-methyl-propyl]-carbamic acid methyl ester
CAS No.:1416718-15-4
Molecular Formula:C₄₀H₄₉N₉O₈S
Molecular Weight:815.951
Hs Code.:

[(S)-1-((S)-2-{5-[4-(6-{3-[(S)-1-((S)-2-methoxycarbonylamino-3-methyl-butyryl)-pyrrolidine-2-carbonyl]-ureido}-benzothiazol-2-yl)-phenyl]-1H-imidazol-2-yl}-pyrrolidine-1-carbonyl)-2-methyl-propyl]-carbamic acid methyl ester

Synonyms:[(S)-1-((S)-2-{5-[4-(6-{3-[(S)-1-((S)-2-methoxycarbonylamino-3-methyl-butyryl)-pyrrolidine-2-carbonyl]-ureido}-benzothiazol-2-yl)-phenyl]-1H-imidazol-2-yl}-pyrrolidine-1-carbonyl)-2-methyl-propyl]-carbamic acid methyl ester

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Chemical Property of [(S)-1-((S)-2-{5-[4-(6-{3-[(S)-1-((S)-2-methoxycarbonylamino-3-methyl-butyryl)-pyrrolidine-2-carbonyl]-ureido}-benzothiazol-2-yl)-phenyl]-1H-imidazol-2-yl}-pyrrolidine-1-carbonyl)-2-methyl-propyl]-carbamic acid methyl ester

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Technology Process of [(S)-1-((S)-2-{5-[4-(6-{3-[(S)-1-((S)-2-methoxycarbonylamino-3-methyl-butyryl)-pyrrolidine-2-carbonyl]-ureido}-benzothiazol-2-yl)-phenyl]-1H-imidazol-2-yl}-pyrrolidine-1-carbonyl)-2-methyl-propyl]-carbamic acid methyl ester

There total 5 articles about [(S)-1-((S)-2-{5-[4-(6-{3-[(S)-1-((S)-2-methoxycarbonylamino-3-methyl-butyryl)-pyrrolidine-2-carbonyl]-ureido}-benzothiazol-2-yl)-phenyl]-1H-imidazol-2-yl}-pyrrolidine-1-carbonyl)-2-methyl-propyl]-carbamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

: 1416718-31-4
methyl (S)-3-methyl-1-oxo-1-((S)-2-(5-(4-(6-(3-(S)-pyrrolidine-2-carbonylureido)benzo[d]thiazol-2-yl)phenyl)-1H-imidazol-2-yl)pyrrolidin-1-yl)butan-2-ylcarbamate

: 111398-44-8,74761-42-5
N-methoxycarbonyl-L-valine

: 1416718-15-4
[(S)-1-((S)-2-{5-[4-(6-{3-[(S)-1-((S)-2-methoxycarbonylamino-3-methyl-butyryl)-pyrrolidine-2-carbonyl]-ureido}-benzothiazol-2-yl)-phenyl]-1H-imidazol-2-yl}-pyrrolidine-1-carbonyl)-2-methyl-propyl]-carbamic acid methyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield:

: 2516-37-2
2-bromo-6-nitro-benzo[d]thiazole

: 1416718-15-4
[(S)-1-((S)-2-{5-[4-(6-{3-[(S)-1-((S)-2-methoxycarbonylamino-3-methyl-butyryl)-pyrrolidine-2-carbonyl]-ureido}-benzothiazol-2-yl)-phenyl]-1H-imidazol-2-yl}-pyrrolidine-1-carbonyl)-2-methyl-propyl]-carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetic acid; iron / 24 h / 20 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / -78 °C

2.3: 20 h / 20 °C

3.1: sodium hydrogencarbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 8 h / 80 °C / Inert atmosphere; Sealed vessel

4.1: trifluoroacetic acid / dichloromethane / 24 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / HATU / N,N-dimethyl-formamide / 1 h / 20 °C

With iron; sodium hydrogencarbonate; acetic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hexamethyldisilazane; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; HATU; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 945400-80-6
2-bromanyl-1,3-benzothiazol-6-amine

: 1416718-15-4
[(S)-1-((S)-2-{5-[4-(6-{3-[(S)-1-((S)-2-methoxycarbonylamino-3-methyl-butyryl)-pyrrolidine-2-carbonyl]-ureido}-benzothiazol-2-yl)-phenyl]-1H-imidazol-2-yl}-pyrrolidine-1-carbonyl)-2-methyl-propyl]-carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / -78 °C

1.3: 20 h / 20 °C

2.1: sodium hydrogencarbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 8 h / 80 °C / Inert atmosphere; Sealed vessel

3.1: trifluoroacetic acid / dichloromethane / 24 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / HATU / N,N-dimethyl-formamide / 1 h / 20 °C

With sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hexamethyldisilazane; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; HATU; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide;