2-Azabicyclo[2.2.1]heptane-3-carbonitrile, 2-(trifluoroacetyl)-, exo- (9CI)

Base Information

Chemical Name:2-Azabicyclo[2.2.1]heptane-3-carbonitrile, 2-(trifluoroacetyl)-, exo- (9CI)
CAS No.:84700-80-1
Molecular Formula:C₉H₉F₃N₂O
Molecular Weight:218.178
Hs Code.:
Mol file:84700-80-1.mol

Synonyms:2-Azabicyclo[2.2.1]heptane-3-carbonitrile, 2-(trifluoroacetyl)-, exo- (9CI)

Suppliers and Price of 2-Azabicyclo[2.2.1]heptane-3-carbonitrile, 2-(trifluoroacetyl)-, exo- (9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 4 raw suppliers

Chemical Property of 2-Azabicyclo[2.2.1]heptane-3-carbonitrile, 2-(trifluoroacetyl)-, exo- (9CI)

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

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Technology Process of 2-Azabicyclo[2.2.1]heptane-3-carbonitrile, 2-(trifluoroacetyl)-, exo- (9CI)

There total 9 articles about 2-Azabicyclo[2.2.1]heptane-3-carbonitrile, 2-(trifluoroacetyl)-, exo- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 20992-42-1,84725-09-7,92591-83-8
(1R,3R,4S)-3-Cyano-2-(toluene-4-sulfonyloxy)-2-aza-bicyclo[2.2.1]hept-5-ene-3-carboxylic acid ethyl ester

: 84700-80-1,84700-81-2,92591-87-2,92591-88-3
exo-3-cyano-2-trifluoroacetyl-2-azabicyclo<2.2.1>heptane

Guidance literature:: Multi-step reaction with 4 steps

1: 95.5 percent / hydrogen / 10percent palladium on barium sulphate / ethyl acetate / 2 h

2: 60 percent / aluminium amalgam, sodium hydrogencarbonate / tetrahydrofuran / 5 h

3: 88 percent / pyridine / 2.5 h

4: calcium chloride dihydrate / dimethylformamide / 2.5 h / 160 °C

With aluminium amalgam; hydrogen; sodium hydrogencarbonate; calcium chloride; Pd-BaSO₄; In tetrahydrofuran; pyridine; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1039/P19840001085

Reference yield:

: 20992-42-1,84725-09-7,92591-83-8
(1R,3R,4S)-3-Cyano-2-(toluene-4-sulfonyloxy)-2-aza-bicyclo[2.2.1]hept-5-ene-3-carboxylic acid ethyl ester

: 84700-80-1,84700-81-2,92591-87-2,92591-88-3
endo-3-cyano-2-trifluoroacetyl-2-azabicyclo<2.2.1>heptane

Guidance literature:: Multi-step reaction with 4 steps

1: 95.5 percent / hydrogen / 10percent palladium on barium sulphate / ethyl acetate / 2 h

2: 60 percent / aluminium amalgam, sodium hydrogencarbonate / tetrahydrofuran / 5 h

3: 88 percent / pyridine / 2.5 h

4: calcium chloride dihydrate / dimethylformamide / 2.5 h / 160 °C

With aluminium amalgam; hydrogen; sodium hydrogencarbonate; calcium chloride; Pd-BaSO₄; In tetrahydrofuran; pyridine; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1039/P19840001085

Reference yield:

: 92591-86-1
exo-3-cyano-endo-3-ethoxycarbonyl-2-trifluoroacetyl-2-azabicyclo<2.2.1>heptane

: 84700-80-1,84700-81-2,92591-87-2,92591-88-3
exo-3-cyano-2-trifluoroacetyl-2-azabicyclo<2.2.1>heptane

: 84700-80-1,84700-81-2,92591-87-2,92591-88-3
endo-3-cyano-2-trifluoroacetyl-2-azabicyclo<2.2.1>heptane

Guidance literature:: With calcium chloride; In N,N-dimethyl-formamide; at 160 ℃; for 2.5h; Title compound not separated from byproducts;
DOI:10.1039/P19840001085