tert-Butyl-[(2S,4R)-2-(2,4-dichloro-6-cyclohexylmethyl-phenoxymethyl)-6-methoxy-tetrahydro-pyran-4-yloxy]-diphenyl-silane

Base Information

Chemical Name:tert-Butyl-[(2S,4R)-2-(2,4-dichloro-6-cyclohexylmethyl-phenoxymethyl)-6-methoxy-tetrahydro-pyran-4-yloxy]-diphenyl-silane
CAS No.:110724-02-2
Molecular Formula:C₃₆H₄₆Cl₂O₄Si
Molecular Weight:641.75
Hs Code.:

Synonyms:tert-Butyl-[(2S,4R)-2-(2,4-dichloro-6-cyclohexylmethyl-phenoxymethyl)-6-methoxy-tetrahydro-pyran-4-yloxy]-diphenyl-silane

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Chemical Property of tert-Butyl-[(2S,4R)-2-(2,4-dichloro-6-cyclohexylmethyl-phenoxymethyl)-6-methoxy-tetrahydro-pyran-4-yloxy]-diphenyl-silane

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Technology Process of tert-Butyl-[(2S,4R)-2-(2,4-dichloro-6-cyclohexylmethyl-phenoxymethyl)-6-methoxy-tetrahydro-pyran-4-yloxy]-diphenyl-silane

There total 8 articles about tert-Butyl-[(2S,4R)-2-(2,4-dichloro-6-cyclohexylmethyl-phenoxymethyl)-6-methoxy-tetrahydro-pyran-4-yloxy]-diphenyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 136007-09-5
2,4-dichloro-6-(cyclohexylmethyl)phenol

: 86031-03-0,108034-28-2,116126-75-1
2(RS)-methoxy-4(R)-(tert-butyldiphenylsilyloxy)-6(S)-(iodomethyl)tetrahydropyran

: 110724-02-2
tert-Butyl-[(2S,4R)-2-(2,4-dichloro-6-cyclohexylmethyl-phenoxymethyl)-6-methoxy-tetrahydro-pyran-4-yloxy]-diphenyl-silane

Guidance literature:: With potassium carbonate; hydroquinone; In dimethyl sulfoxide; at 40 ℃; for 1h;
DOI:10.1021/jm00114a004

Reference yield:

: 110772-23-1
[(2S,4R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-methoxy-tetrahydro-pyran-2-yl]-methanol

: 110724-02-2
tert-Butyl-[(2S,4R)-2-(2,4-dichloro-6-cyclohexylmethyl-phenoxymethyl)-6-methoxy-tetrahydro-pyran-4-yloxy]-diphenyl-silane

Guidance literature:: Multi-step reaction with 3 steps

1: 98 percent / pyridine / CH₂Cl₂ / 3 h / Ambient temperature

2: 90 percent / NaI / acetone / 24 h / Heating

3: K₂CO₃, hydroquinone / dimethylsulfoxide / 1 h / 40 °C

With pyridine; potassium carbonate; hydroquinone; sodium iodide; In dichloromethane; dimethyl sulfoxide; acetone;
DOI:10.1021/jm00114a004

Reference yield:

: Cyclohexanecarboxylic acid 2,4-dichloro-phenyl ester

: 110724-02-2
tert-Butyl-[(2S,4R)-2-(2,4-dichloro-6-cyclohexylmethyl-phenoxymethyl)-6-methoxy-tetrahydro-pyran-4-yloxy]-diphenyl-silane

Guidance literature:: Multi-step reaction with 4 steps

1: AlCl₃ / 4 h / 150 °C

2: NaBH₄ / methanol / 1 h / 20 °C

3: 77 percent / LiAlH₄, AlCl₃ / diethyl ether / 1 h / 80 °C

4: K₂CO₃, hydroquinone / dimethylsulfoxide / 1 h / 40 °C

With sodium tetrahydroborate; lithium aluminium tetrahydride; aluminium trichloride; potassium carbonate; hydroquinone; In methanol; diethyl ether; dimethyl sulfoxide;
DOI:10.1021/jm00114a004