(1S,3S)-methyl 1,2,3,4-tetrahydro-1-(2-methylpropyl)-7-(2-nitrobenzyloxy)-9H-pyrido<3,4-b>indole-3-carboxylate

Base Information

Chemical Name:(1S,3S)-methyl 1,2,3,4-tetrahydro-1-(2-methylpropyl)-7-(2-nitrobenzyloxy)-9H-pyrido<3,4-b>indole-3-carboxylate
CAS No.:175975-82-3
Molecular Formula:C₂₄H₂₇N₃O₅
Molecular Weight:437.495
Hs Code.:

Synonyms:(1S,3S)-methyl 1,2,3,4-tetrahydro-1-(2-methylpropyl)-7-(2-nitrobenzyloxy)-9H-pyrido<3,4-b>indole-3-carboxylate

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Chemical Property of (1S,3S)-methyl 1,2,3,4-tetrahydro-1-(2-methylpropyl)-7-(2-nitrobenzyloxy)-9H-pyrido<3,4-b>indole-3-carboxylate

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Technology Process of (1S,3S)-methyl 1,2,3,4-tetrahydro-1-(2-methylpropyl)-7-(2-nitrobenzyloxy)-9H-pyrido<3,4-b>indole-3-carboxylate

There total 1 articles about (1S,3S)-methyl 1,2,3,4-tetrahydro-1-(2-methylpropyl)-7-(2-nitrobenzyloxy)-9H-pyrido<3,4-b>indole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

: (S)-6-(2-nitrobenzyloxy)triptophan methyl ester

: 590-86-3
isovaleraldehyde

: 175975-82-3
(1S,3S)-methyl 1,2,3,4-tetrahydro-1-(2-methylpropyl)-7-(2-nitrobenzyloxy)-9H-pyrido<3,4-b>indole-3-carboxylate

: (1R,3S)-methyl 1,2,3,4-tetrahydro-1-(2-methylpropyl)-7-(2-nitrobenzyloxy)-9H-pyrido<3,4-b>indole-3-carboxylate

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 25 ℃; for 4h;
DOI:10.1002/hlca.19960790116

Reference yield: 97.0%

: 175975-82-3
(1S,3S)-methyl 1,2,3,4-tetrahydro-1-(2-methylpropyl)-7-(2-nitrobenzyloxy)-9H-pyrido<3,4-b>indole-3-carboxylate

: 175975-83-4
(1S,3S)-1,2,3,4-tetrahydro-1-(2-methylpropyl)-7-(2-nitrobenzyloxy)-9H-pyrido<3,4-b>indole-3-carboxamide

Guidance literature:: With ammonia; at 25 ℃; for 96h;
DOI:10.1002/hlca.19960790116

Reference yield:

: 175975-82-3
(1S,3S)-methyl 1,2,3,4-tetrahydro-1-(2-methylpropyl)-7-(2-nitrobenzyloxy)-9H-pyrido<3,4-b>indole-3-carboxylate

: 175975-84-5
(S)-2-(benzyloxycarbonyl)-1,2,3,4-tetrahydro-1-(2-methylpropyl)-7-(2-nitrobenzyloxy)-9H-pyrido<3,4-b>-indole

Guidance literature:: Multi-step reaction with 4 steps

1: 97 percent / NH₃ sat. MeOH / 96 h / 25 °C

2: pyridine / dioxane

3: 57 percent / pyridine, NaBH₄ / ethanol / 12 h / 40 °C

4: 92 percent / Et₃N / CH₂Cl₂ / 0.33 h / 25 °C

With pyridine; sodium tetrahydroborate; ammonia; triethylamine; In 1,4-dioxane; ethanol; dichloromethane;
DOI:10.1002/hlca.19960790116