methyl 8-isopropoxy-2-(2-isopropoxy-4,5-dimethoxyphenyl)-1-(3-isopropoxyphenyl)-9-methoxy-5,6-dihydropyrrolo[2,1-a]isoquinoline-3-carboxylate

Base Information

Chemical Name:methyl 8-isopropoxy-2-(2-isopropoxy-4,5-dimethoxyphenyl)-1-(3-isopropoxyphenyl)-9-methoxy-5,6-dihydropyrrolo[2,1-a]isoquinoline-3-carboxylate
CAS No.:897018-51-8
Molecular Formula:C₃₈H₄₅NO₈
Molecular Weight:643.777
Hs Code.:

methyl 8-isopropoxy-2-(2-isopropoxy-4,5-dimethoxyphenyl)-1-(3-isopropoxyphenyl)-9-methoxy-5,6-dihydropyrrolo[2,1-a]isoquinoline-3-carboxylate

Synonyms:methyl 8-isopropoxy-2-(2-isopropoxy-4,5-dimethoxyphenyl)-1-(3-isopropoxyphenyl)-9-methoxy-5,6-dihydropyrrolo[2,1-a]isoquinoline-3-carboxylate

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Chemical Property of methyl 8-isopropoxy-2-(2-isopropoxy-4,5-dimethoxyphenyl)-1-(3-isopropoxyphenyl)-9-methoxy-5,6-dihydropyrrolo[2,1-a]isoquinoline-3-carboxylate

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Technology Process of methyl 8-isopropoxy-2-(2-isopropoxy-4,5-dimethoxyphenyl)-1-(3-isopropoxyphenyl)-9-methoxy-5,6-dihydropyrrolo[2,1-a]isoquinoline-3-carboxylate

There total 6 articles about methyl 8-isopropoxy-2-(2-isopropoxy-4,5-dimethoxyphenyl)-1-(3-isopropoxyphenyl)-9-methoxy-5,6-dihydropyrrolo[2,1-a]isoquinoline-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 2-(4,5-dimethoxy-2-isopropoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 897018-44-9
methyl 2-bromo-8-isopropoxy-1-(3-isopropoxyphenyl)-9-methoxy-5,6-dihydropyrrolo[2,1-a]isoquinoline-3-carboxylate

: 897018-51-8
methyl 8-isopropoxy-2-(2-isopropoxy-4,5-dimethoxyphenyl)-1-(3-isopropoxyphenyl)-9-methoxy-5,6-dihydropyrrolo[2,1-a]isoquinoline-3-carboxylate

Guidance literature:: With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 115 ℃; for 16h;
DOI:10.1021/jm0602458

Reference yield:

: 850346-70-2
methyl 1-[2-bromo-5-isopropoxy-4-methoxyphenethyl]-1H-pyrrole-2-carboxylate

: 897018-51-8
methyl 8-isopropoxy-2-(2-isopropoxy-4,5-dimethoxyphenyl)-1-(3-isopropoxyphenyl)-9-methoxy-5,6-dihydropyrrolo[2,1-a]isoquinoline-3-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: 81 percent / K₂CO₃; PPh₃; PdCl₂(PPh₃)2 / dimethylformamide / 20 h / 125 °C

2: 94 percent / N-bromosuccinimide / tetrahydrofuran / 3 h / 70 °C

3: 89 percent / Pd(PPh₃)4; aq. K₂CO₃ / dimethylformamide / 5 h / 125 °C

4: 100 percent / N-bromosuccinimide / tetrahydrofuran / 1.5 h / 70 °C

5: 93 percent / Pd(PPh₃)4; aq. K₃PO₄ / dimethylformamide / 16 h / 115 °C

With bis-triphenylphosphine-palladium(II) chloride; potassium phosphate; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide; 3: Suzuki cross-coupling / 5: Suzuki cross-coupling;
DOI:10.1021/jm0602458

Reference yield:

: 850346-72-4
methyl 8-isopropoxy-9-methoxy-5,6-dihydropyrrolo[2,1-a]isoquinoline-3-carboxylate

: 897018-51-8
methyl 8-isopropoxy-2-(2-isopropoxy-4,5-dimethoxyphenyl)-1-(3-isopropoxyphenyl)-9-methoxy-5,6-dihydropyrrolo[2,1-a]isoquinoline-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 94 percent / N-bromosuccinimide / tetrahydrofuran / 3 h / 70 °C

2: 89 percent / Pd(PPh₃)4; aq. K₂CO₃ / dimethylformamide / 5 h / 125 °C

3: 100 percent / N-bromosuccinimide / tetrahydrofuran / 1.5 h / 70 °C

4: 93 percent / Pd(PPh₃)4; aq. K₃PO₄ / dimethylformamide / 16 h / 115 °C

With potassium phosphate; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; 2: Suzuki cross-coupling / 4: Suzuki cross-coupling;
DOI:10.1021/jm0602458