[2-[5-[6-(1-benzyloxymethyl-propyl)-4-cyano-2,2-dimethyl-[1,3]dioxan-4-yl]-2-(tert-butyl-dimethyl-silanyloxy)-pentyl]-4-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-2-methoxy-hexahydro-pyrano[4,3-b]pyran-7-ylmethyl]-phosphonic acid diethyl ester

Base Information

Chemical Name:[2-[5-[6-(1-benzyloxymethyl-propyl)-4-cyano-2,2-dimethyl-[1,3]dioxan-4-yl]-2-(tert-butyl-dimethyl-silanyloxy)-pentyl]-4-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-2-methoxy-hexahydro-pyrano[4,3-b]pyran-7-ylmethyl]-phosphonic acid diethyl ester
CAS No.:724765-13-3
Molecular Formula:C₄₉H₈₈NO₁₂PSi₂
Molecular Weight:970.382
Hs Code.:

[2-[5-[6-(1-benzyloxymethyl-propyl)-4-cyano-2,2-dimethyl-[1,3]dioxan-4-yl]-2-(<i>tert</i>-butyl-dimethyl-silanyloxy)-pentyl]-4-(<i>tert</i>-butyl-dimethyl-silanyloxy)-5-hydroxy-2-methoxy-hexahydro-pyrano[4,3-<i>b</i>]pyran-7-ylmethyl]-phosphonic acid diethyl ester

Synonyms:[2-[5-[6-(1-benzyloxymethyl-propyl)-4-cyano-2,2-dimethyl-[1,3]dioxan-4-yl]-2-(tert-butyl-dimethyl-silanyloxy)-pentyl]-4-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-2-methoxy-hexahydro-pyrano[4,3-b]pyran-7-ylmethyl]-phosphonic acid diethyl ester

Suppliers and Price of [2-[5-[6-(1-benzyloxymethyl-propyl)-4-cyano-2,2-dimethyl-[1,3]dioxan-4-yl]-2-(tert-butyl-dimethyl-silanyloxy)-pentyl]-4-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-2-methoxy-hexahydro-pyrano[4,3-b]pyran-7-ylmethyl]-phosphonic acid diethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of [2-[5-[6-(1-benzyloxymethyl-propyl)-4-cyano-2,2-dimethyl-[1,3]dioxan-4-yl]-2-(tert-butyl-dimethyl-silanyloxy)-pentyl]-4-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-2-methoxy-hexahydro-pyrano[4,3-b]pyran-7-ylmethyl]-phosphonic acid diethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of [2-[5-[6-(1-benzyloxymethyl-propyl)-4-cyano-2,2-dimethyl-[1,3]dioxan-4-yl]-2-(tert-butyl-dimethyl-silanyloxy)-pentyl]-4-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-2-methoxy-hexahydro-pyrano[4,3-b]pyran-7-ylmethyl]-phosphonic acid diethyl ester

There total 30 articles about [2-[5-[6-(1-benzyloxymethyl-propyl)-4-cyano-2,2-dimethyl-[1,3]dioxan-4-yl]-2-(tert-butyl-dimethyl-silanyloxy)-pentyl]-4-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-2-methoxy-hexahydro-pyrano[4,3-b]pyran-7-ylmethyl]-phosphonic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 724765-27-9
{3-[6-[5-[6-(1-benzyloxymethyl-propyl)-4-cyano-2,2-dimethyl-[1,3]dioxan-4-yl]-2-(tert-butyl-dimethyl-silanyloxy)-pentyl]-4-(tert-butyl-dimethyl-silanyloxy)-6-methoxy-3-vinyl-tetrahydro-pyran-2-yl]-2-hydroxy-propyl}-phosphonic acid diethyl ester

: 724765-13-3
[2-[5-[6-(1-benzyloxymethyl-propyl)-4-cyano-2,2-dimethyl-[1,3]dioxan-4-yl]-2-(tert-butyl-dimethyl-silanyloxy)-pentyl]-4-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-2-methoxy-hexahydro-pyrano[4,3-b]pyran-7-ylmethyl]-phosphonic acid diethyl ester

Guidance literature:: {3-[6-[5-[6-(1-benzyloxymethyl-propyl)-4-cyano-2,2-dimethyl-[1,3]dioxan-4-yl]-2-(tert-butyl-dimethyl-silanyloxy)-pentyl]-4-(tert-butyl-dimethyl-silanyloxy)-6-methoxy-3-vinyl-tetrahydro-pyran-2-yl]-2-hydroxy-propyl}-phosphonic acid diethyl ester; With oil scarlet; ozone; sodium sulfite; In methanol; dichloromethane; at -78 ℃;

With triethyl phosphite; In methanol; dichloromethane;
DOI:10.1002/anie.200453697

Reference yield:

: 127793-67-3
(S)‐7‐(benzyloxy)hept‐1‐en‐4‐ol

: 724765-13-3
[2-[5-[6-(1-benzyloxymethyl-propyl)-4-cyano-2,2-dimethyl-[1,3]dioxan-4-yl]-2-(tert-butyl-dimethyl-silanyloxy)-pentyl]-4-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-2-methoxy-hexahydro-pyrano[4,3-b]pyran-7-ylmethyl]-phosphonic acid diethyl ester

Guidance literature:: Multi-step reaction with 16 steps

1.1: O₃ / CH₂Cl₂; methanol / -78 °C

1.2: 97 percent / NaBH₄ / CH₂Cl₂; methanol / 1.5 h / -78 - 23 °C

2.1: TEMPO; aq. KBr; NaOCl / NaHCO₃ / CH₂Cl₂ / 0.33 h / 0 °C

3.1: 18-crown-6; TMSCN / CH₂Cl₂ / 1 h / 23 °C

3.2: 1.14 g / pyridinium p-toluenesulfonate / CH₂Cl₂; methanol / 5 h / 23 °C

4.1: 88 percent / pyridinium p-toluenesulfonate / acetone / 19 h / 68 °C

5.1: 92 percent / LDA; N,N'-dimethyl-N,N'-propyleneurea / tetrahydrofuran; hexane / 0.5 h / -40 °C

6.1: Dowex 50X₂-100 ion-exchange resin; H₂O / methanol / 12 h / 23 °C

7.1: 0.74 g / Et₃N / methanol / 23 °C

8.1: 89 percent / pyridinium p-toluenesulfonate / methanol / 24 h / 23 °C

9.1: 97 percent / imidazole; DMAP / dimethylformamide / 13 h / 23 °C

10.1: 93 percent / Li; NH₃ / tetrahydrofuran / 0.2 h / -78 °C

11.1: 92 percent / I₂; PPh₃; imidazole / benzene / 0.17 h / 23 °C

12.1: 93 percent / LDA; N,N'-dimethyl-N,N'-propyleneurea / tetrahydrofuran; hexane / 0.25 h / -40 °C

13.1: 91 percent / NMO; OsO₄ / 2-methyl-propan-2-ol; H₂O / 12.75 h / 23 °C

14.1: 94 percent / Pb(OAc)4; Na₂CO₃ / CH₂Cl₂ / 0.75 h / -10 - 23 °C

15.1: 90 percent / n-BuLi; DMPU / tetrahydrofuran / 0.25 h / -78 °C

With 1H-imidazole; lead(IV) acetate; dmap; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; osmium(VIII) oxide; n-butyllithium; N-methyl-2-indolinone; 18-crown-6 ether; trimethylsilyl cyanide; Dowex 50X₂-100 ion-exchange resin; ammonia; water; iodine; pyridinium p-toluenesulfonate; lithium; sodium carbonate; ozone; triethylamine; triphenylphosphine; potassium bromide; lithium diisopropyl amide; sodium hydrogencarbonate; In tetrahydrofuran; methanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; acetone; tert-butyl alcohol; benzene;
DOI:10.1002/anie.200453697

Reference yield:

: 83458-93-9
(3S)-6-(Benzyloxy)hexane-1,3-diol

: 724765-13-3
[2-[5-[6-(1-benzyloxymethyl-propyl)-4-cyano-2,2-dimethyl-[1,3]dioxan-4-yl]-2-(tert-butyl-dimethyl-silanyloxy)-pentyl]-4-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-2-methoxy-hexahydro-pyrano[4,3-b]pyran-7-ylmethyl]-phosphonic acid diethyl ester

Guidance literature:: Multi-step reaction with 15 steps

1.1: TEMPO; aq. KBr; NaOCl / NaHCO₃ / CH₂Cl₂ / 0.33 h / 0 °C

2.1: 18-crown-6; TMSCN / CH₂Cl₂ / 1 h / 23 °C

2.2: 1.14 g / pyridinium p-toluenesulfonate / CH₂Cl₂; methanol / 5 h / 23 °C

3.1: 88 percent / pyridinium p-toluenesulfonate / acetone / 19 h / 68 °C

4.1: 92 percent / LDA; N,N'-dimethyl-N,N'-propyleneurea / tetrahydrofuran; hexane / 0.5 h / -40 °C

5.1: Dowex 50X₂-100 ion-exchange resin; H₂O / methanol / 12 h / 23 °C

6.1: 0.74 g / Et₃N / methanol / 23 °C

7.1: 89 percent / pyridinium p-toluenesulfonate / methanol / 24 h / 23 °C

8.1: 97 percent / imidazole; DMAP / dimethylformamide / 13 h / 23 °C

9.1: 93 percent / Li; NH₃ / tetrahydrofuran / 0.2 h / -78 °C

10.1: 92 percent / I₂; PPh₃; imidazole / benzene / 0.17 h / 23 °C

11.1: 93 percent / LDA; N,N'-dimethyl-N,N'-propyleneurea / tetrahydrofuran; hexane / 0.25 h / -40 °C

12.1: 91 percent / NMO; OsO₄ / 2-methyl-propan-2-ol; H₂O / 12.75 h / 23 °C

13.1: 94 percent / Pb(OAc)4; Na₂CO₃ / CH₂Cl₂ / 0.75 h / -10 - 23 °C

14.1: 90 percent / n-BuLi; DMPU / tetrahydrofuran / 0.25 h / -78 °C

With 1H-imidazole; lead(IV) acetate; dmap; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; osmium(VIII) oxide; n-butyllithium; N-methyl-2-indolinone; 18-crown-6 ether; trimethylsilyl cyanide; Dowex 50X₂-100 ion-exchange resin; ammonia; water; iodine; pyridinium p-toluenesulfonate; lithium; sodium carbonate; triethylamine; triphenylphosphine; potassium bromide; lithium diisopropyl amide; sodium hydrogencarbonate; In tetrahydrofuran; methanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; acetone; tert-butyl alcohol; benzene;
DOI:10.1002/anie.200453697