(S)-2-imino-6-(3'-methoxy-[1,1'-biphenyl]-3-yl)-3,6-dimethyltetrahydropyrimidin-4(1H)-one.trifluroacetate

Base Information

Chemical Name:(S)-2-imino-6-(3'-methoxy-[1,1'-biphenyl]-3-yl)-3,6-dimethyltetrahydropyrimidin-4(1H)-one.trifluroacetate
CAS No.:1392015-29-0
Molecular Formula:C₂HF₃O₂*C₁₉H₂₁N₃O₂
Molecular Weight:437.419
Hs Code.:

Synonyms:(S)-2-imino-6-(3'-methoxy-[1,1'-biphenyl]-3-yl)-3,6-dimethyltetrahydropyrimidin-4(1H)-one.trifluroacetate

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Chemical Property of (S)-2-imino-6-(3'-methoxy-[1,1'-biphenyl]-3-yl)-3,6-dimethyltetrahydropyrimidin-4(1H)-one.trifluroacetate

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Technology Process of (S)-2-imino-6-(3'-methoxy-[1,1'-biphenyl]-3-yl)-3,6-dimethyltetrahydropyrimidin-4(1H)-one.trifluroacetate

There total 6 articles about (S)-2-imino-6-(3'-methoxy-[1,1'-biphenyl]-3-yl)-3,6-dimethyltetrahydropyrimidin-4(1H)-one.trifluroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1392015-28-9
C₂₄H₂₉N₃O₄

: 76-05-1
trifluoroacetic acid

: 1392015-29-0
(S)-2-imino-6-(3'-methoxy-[1,1'-biphenyl]-3-yl)-3,6-dimethyltetrahydropyrimidin-4(1H)-one.trifluroacetate

Guidance literature:: In dichloromethane; at 20 ℃; for 1h;
DOI:10.1021/ml3001165

Reference yield:

: 1075230-53-3
(R)-N-(1-(3-bromophenyl)ethylidene)-2-methylpropane-2-sulfinamid

: 1392015-29-0
(S)-2-imino-6-(3'-methoxy-[1,1'-biphenyl]-3-yl)-3,6-dimethyltetrahydropyrimidin-4(1H)-one.trifluroacetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

1.2: 2 h / -78 °C / Inert atmosphere

2.1: hydrogenchloride / 1,4-dioxane; methanol / 1.5 h / 20 °C

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / tetrahydrofuran; N,N-dimethyl-formamide / 50 °C

4.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / dichloromethane; tert-butyl alcohol / 1.5 h / 60 °C

5.1: dichloromethane / 1 h / 20 °C

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; n-butyllithium; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diisopropylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1021/ml3001165

Reference yield:

: 887913-53-3
(S)-tert-butyl 4-(3-bromophenyl)-1,4-dimethyl-6-oxotetrahydropyrimidin-2(1H)-ylidenecarbamate

: 1392015-29-0
(S)-2-imino-6-(3'-methoxy-[1,1'-biphenyl]-3-yl)-3,6-dimethyltetrahydropyrimidin-4(1H)-one.trifluroacetate

Guidance literature:: Multi-step reaction with 2 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / dichloromethane; tert-butyl alcohol / 1.5 h / 60 °C

2: dichloromethane / 1 h / 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In dichloromethane; tert-butyl alcohol;
DOI:10.1021/ml3001165