N-tert-butoxycarbonyl-O-benzyloxycarbonyl-N-phenethylhydroxylamine

Base Information

• Chemical Name: N-tert-butoxycarbonyl-O-benzyloxycarbonyl-N-phenethylhydroxylamine
• CAS No.: 1590361-17-3
• Molecular Formula: C₂₁H₂₅NO₅
• Molecular Weight: 371.433
• Mol file: 1590361-17-3.mol

Synonyms:N-tert-butoxycarbonyl-O-benzyloxycarbonyl-N-phenethylhydroxylamine

Chemical Property of N-tert-butoxycarbonyl-O-benzyloxycarbonyl-N-phenethylhydroxylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-tert-butoxycarbonyl-O-benzyloxycarbonyl-N-phenethylhydroxylamine

There total 4 articles about N-tert-butoxycarbonyl-O-benzyloxycarbonyl-N-phenethylhydroxylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

N-tert-butoxycarbonyl-N-phenethylhydroxylamine + benzyl chloroformate (501-53-1,94274-21-2) → N-tert-butoxycarbonyl-O-benzyloxycarbonyl-N-phenethylhydroxylamine (1590361-17-3)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 8h; Inert atmosphere;

DOI:10.1021/ja5018442

Reference yield:

O-benzoyl-N-tert-butoxycarbonyl-N-phenethylhydroxylamine (1590361-13-9) → N-tert-butoxycarbonyl-O-benzyloxycarbonyl-N-phenethylhydroxylamine (1590361-17-3)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / methanol / 15 h / 20 °C / Inert atmosphere

2: triethylamine / dichloromethane / 8 h / 0 - 20 °C / Inert atmosphere

With potassium carbonate; triethylamine; In methanol; dichloromethane;

DOI:10.1021/ja5018442

Reference yield:

1-phenyl-2-bromoethane (103-63-9) → N-tert-butoxycarbonyl-O-benzyloxycarbonyl-N-phenethylhydroxylamine (1590361-17-3)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 20 °C / Inert atmosphere

2: potassium carbonate / methanol / 15 h / 20 °C / Inert atmosphere

3: triethylamine / dichloromethane / 8 h / 0 - 20 °C / Inert atmosphere

With potassium carbonate; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ja5018442

upstream raw materials:

benzyl chloroformate

O-benzoyl-N-tert-butoxycarbonyl-N-phenethylhydroxylamine

(benzyloxy)carbamic acid 1,1-dimethylethyl ester

1-phenyl-2-bromoethane

Downstream raw materials:

O-benzyloxycarbonyl-N-phenethylhydroxylamine

N-(2-phenylethyl)-4-fluorobenzamide