4-formyl-1-phenyl-1H-pyrazol-3-yl trifluoromethanesulfonate

Base Information

• Chemical Name: 4-formyl-1-phenyl-1H-pyrazol-3-yl trifluoromethanesulfonate
• CAS No.: 1354413-51-6
• Molecular Formula: C₁₁H₇F₃N₂O₄S
• Molecular Weight: 320.249
• Mol file: 1354413-51-6.mol

Synonyms:4-formyl-1-phenyl-1H-pyrazol-3-yl trifluoromethanesulfonate

Chemical Property of 4-formyl-1-phenyl-1H-pyrazol-3-yl trifluoromethanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-formyl-1-phenyl-1H-pyrazol-3-yl trifluoromethanesulfonate

There total 7 articles about 4-formyl-1-phenyl-1H-pyrazol-3-yl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

3-hydroxy-1-phenyl-1H-pyrazole-4-carbaldehyde + trifluoromethylsulfonic anhydride (358-23-6) → 4-formyl-1-phenyl-1H-pyrazol-3-yl trifluoromethanesulfonate (1354413-51-6)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 1h;

DOI:10.3998/ark.5550190.0012.b01

Reference yield:

1-phenyl-1H-pyrazol-3-ol (1008-79-3) → 4-formyl-1-phenyl-1H-pyrazol-3-yl trifluoromethanesulfonate (1354413-51-6)

Guidance literature:

Multi-step reaction with 5 steps

1.1: bromine / chloroform / 20 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C / Inert atmosphere

2.2: 1 h / 60 °C / Inert atmosphere

3.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 - 20 °C / Inert atmosphere

4.1: trifluoroacetic acid / toluene / 48 h / 20 °C

5.1: triethylamine / dichloromethane / 1 h / 20 °C

With n-butyllithium; bromine; sodium hydride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; hexane; dichloromethane; chloroform; N,N-dimethyl-formamide; toluene; mineral oil;

DOI:10.3998/ark.5550190.0012.b01

Reference yield:

3-(benzyloxy)-1-phenyl-1H-pyrazole-4-carbaldehyde (464185-13-5) → 4-formyl-1-phenyl-1H-pyrazol-3-yl trifluoromethanesulfonate (1354413-51-6)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid / toluene / 48 h / 20 °C

2: triethylamine / dichloromethane / 1 h / 20 °C

With triethylamine; trifluoroacetic acid; In dichloromethane; toluene;

DOI:10.3998/ark.5550190.0012.b01

upstream raw materials:

3-(benzyloxy)-4-bromo-1-phenyl-1H-pyrazole

3-(benzyloxy)-1-phenyl-1H-pyrazole-4-carbaldehyde

3-(benzyloxy)-1-phenyl-1H-pyrazol

trifluoromethylsulfonic anhydride

Downstream raw materials:

1-phenyl-3-[(E)-2-phenylethenyl]-1H-pyrazole-4-carbaldehyde

1-phenyl-3-(thiophen-3-yl)-1H-pyrazole-4-carboxaldehyde

2,6-diphenyl-2H-pyrazolo[4,3-c]pyridine

tert-butyl (2E)-3-(4-formyl-1-phenyl-1H-pyrazol-3-yl)acrylate