N-(((1,1-dimethylethyl)oxy)carbonyl)-N-(1,3-thiazol-4-ylmethyl)-L-phenylalanine

Base Information

• Chemical Name: N-(((1,1-dimethylethyl)oxy)carbonyl)-N-(1,3-thiazol-4-ylmethyl)-L-phenylalanine
• CAS No.: 1240521-21-4
• Molecular Formula: C₁₈H₂₂N₂O₄S
• Molecular Weight: 362.45
• Mol file: 1240521-21-4.mol

Synonyms:N-(((1,1-dimethylethyl)oxy)carbonyl)-N-(1,3-thiazol-4-ylmethyl)-L-phenylalanine

Chemical Property of N-(((1,1-dimethylethyl)oxy)carbonyl)-N-(1,3-thiazol-4-ylmethyl)-L-phenylalanine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(((1,1-dimethylethyl)oxy)carbonyl)-N-(1,3-thiazol-4-ylmethyl)-L-phenylalanine

There total 5 articles about N-(((1,1-dimethylethyl)oxy)carbonyl)-N-(1,3-thiazol-4-ylmethyl)-L-phenylalanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

methyl N-(((1,1-dimethylethyl)oxy)carbonyl)-N-(1,3-thiazol-4-ylmethyl)-L-phenylalaninate (1240521-20-3) → N-(((1,1-dimethylethyl)oxy)carbonyl)-N-(1,3-thiazol-4-ylmethyl)-L-phenylalanine (1240521-21-4)

Guidance literature:

methyl N-(((1,1-dimethylethyl)oxy)carbonyl)-N-(1,3-thiazol-4-ylmethyl)-L-phenylalaninate; With lithium hydroxide; In 1,4-dioxane; at 20 ℃; for 0.583333h;

With acetic acid; In 1,4-dioxane; Product distribution / selectivity;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → N-(((1,1-dimethylethyl)oxy)carbonyl)-N-(1,3-thiazol-4-ylmethyl)-L-phenylalanine (1240521-21-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1 h / 50 °C

2: lithium hydroxide / 1,4-dioxane / 0.58 h / 20 °C

With lithium hydroxide; In 1,4-dioxane;

Reference yield:

(S)-methyl 3-phenyl-2-(thiazol-4-ylmethylamino)propanoate (1240523-18-5) → N-(((1,1-dimethylethyl)oxy)carbonyl)-N-(1,3-thiazol-4-ylmethyl)-L-phenylalanine (1240521-21-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1 h / 50 °C

2: lithium hydroxide / 1,4-dioxane / 0.58 h / 20 °C

With lithium hydroxide; In 1,4-dioxane;

upstream raw materials:

methyl N-(((1,1-dimethylethyl)oxy)carbonyl)-N-(1,3-thiazol-4-ylmethyl)-L-phenylalaninate

di-tert-butyl dicarbonate

(S)-methyl 3-phenyl-2-(thiazol-4-ylmethylamino)propanoate

(S)-2-tert-butoxycarbonylamino-3-phenyl-propionic acid methyl ester

Downstream raw materials:

(S)-tert-butyl 1-fluoro-1-oxo-3-phenylpropan-2-yl(thiazol-4-ylmethyl)carbamate

(S)-3-phenyl-N-(5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)-2-(thiazol-4-ylmethylamino)propanamide

(S)-tert-butyl 1-oxo-3-phenyl-1-(5-(pyridin-4-yl)-4H-1,2,4-triazol-3-ylamino)propan-2-yl(thiazol-4-ylmethyl)carbamate