(3-benzyloxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-yl)-(4-methoxy-phenyl)-phosphinic acid methyl ester

Base Information

Chemical Name:(3-benzyloxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-yl)-(4-methoxy-phenyl)-phosphinic acid methyl ester
CAS No.:362476-84-4
Molecular Formula:C₂₅H₂₇N₂O₅P
Molecular Weight:466.474
Hs Code.:

(3-benzyloxycarbamoyl-3,4-dihydro-1<i>H</i>-isoquinolin-2-yl)-(4-methoxy-phenyl)-phosphinic acid methyl ester

Synonyms:(3-benzyloxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-yl)-(4-methoxy-phenyl)-phosphinic acid methyl ester

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Chemical Property of (3-benzyloxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-yl)-(4-methoxy-phenyl)-phosphinic acid methyl ester

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Technology Process of (3-benzyloxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-yl)-(4-methoxy-phenyl)-phosphinic acid methyl ester

There total 5 articles about (3-benzyloxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-yl)-(4-methoxy-phenyl)-phosphinic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 622-33-3
N-benzyloxyamine

: 362476-84-4
(3-benzyloxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-yl)-(4-methoxy-phenyl)-phosphinic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 41 percent / WSC; HOBt; triethylamine / dimethylformamide / 20 °C

2: 4.6 g / 4N HCl / ethyl acetate / 2 h / 20 °C

3: pyridine / 0.25 h / 20 °C

4: pyridine / 1 h / 20 °C

With pyridine; hydrogenchloride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm0103211

Reference yield:

: 362477-34-7
(3R)-N-benzyloxy-2-tert-butoxycarbonyl-1,2,3,4-tetrahydroisoquinoline-3-carboxamide

: 362476-84-4
(3-benzyloxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-yl)-(4-methoxy-phenyl)-phosphinic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 4.6 g / 4N HCl / ethyl acetate / 2 h / 20 °C

2: pyridine / 0.25 h / 20 °C

3: pyridine / 1 h / 20 °C

With pyridine; hydrogenchloride; In ethyl acetate;
DOI:10.1021/jm0103211