Ethyl (2R,3R,4R,5S)-4-acetyl-3-<(1S)-1,2-O-cyclohexylideneethyl>-5-phenylpyrrolidine-2-carboxylate

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Chemical Name:Ethyl (2R,3R,4R,5S)-4-acetyl-3-<(1S)-1,2-O-cyclohexylideneethyl>-5-phenylpyrrolidine-2-carboxylate
CAS No.:153186-40-4
Molecular Formula:C₂₃H₃₁NO₅
Molecular Weight:401.503
Hs Code.:

Synonyms:Ethyl (2R,3R,4R,5S)-4-acetyl-3-<(1S)-1,2-O-cyclohexylideneethyl>-5-phenylpyrrolidine-2-carboxylate

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Chemical Property of Ethyl (2R,3R,4R,5S)-4-acetyl-3-<(1S)-1,2-O-cyclohexylideneethyl>-5-phenylpyrrolidine-2-carboxylate

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Technology Process of Ethyl (2R,3R,4R,5S)-4-acetyl-3-<(1S)-1,2-O-cyclohexylideneethyl>-5-phenylpyrrolidine-2-carboxylate

There total 3 articles about Ethyl (2R,3R,4R,5S)-4-acetyl-3-<(1S)-1,2-O-cyclohexylideneethyl>-5-phenylpyrrolidine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 133038-44-5
[(benzylidene)amino]acetic acid ethyl ester

: 153186-36-8
(5S,3E)-5,6-O-cyclohexylidene-hex-3-en-2-one

: 153186-40-4
Ethyl (2R,3R,4R,5S)-4-acetyl-3-<(1S)-1,2-O-cyclohexylideneethyl>-5-phenylpyrrolidine-2-carboxylate

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; silver(I) acetate; In tetrahydrofuran; at -78 ℃; for 4h;
DOI:10.1016/S0040-4039(00)73839-1

Reference yield:

: 78008-36-3
(R)-2,3-cyclohexylideneglyceraldehyde

: 153186-40-4
Ethyl (2R,3R,4R,5S)-4-acetyl-3-<(1S)-1,2-O-cyclohexylideneethyl>-5-phenylpyrrolidine-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: benzene; diethyl ether / Ambient temperature

2: 95 percent / DBU / AgOAc / tetrahydrofuran / 4 h / -78 °C

With 1,8-diazabicyclo[5.4.0]undec-7-ene; silver(I) acetate; In tetrahydrofuran; diethyl ether; benzene;
DOI:10.1016/S0040-4039(00)73839-1

Reference yield:

: 169962-99-6
Benzylidene glycine amide

: 153186-36-8
(5S,3E)-5,6-O-cyclohexylidene-hex-3-en-2-one

: 153186-40-4
Ethyl (2R,3R,4R,5S)-4-acetyl-3-<(1S)-1,2-O-cyclohexylideneethyl>-5-phenylpyrrolidine-2-carboxylate

: Ethyl (2S,3S,4S,5R)-4-acetyl-3-<(1S)-1,2-O-cyclohexylideneethyl>-5-phenylpyrrolidine-2-carboxylate

Guidance literature:: With silver(I) acetate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; Product distribution; 1.) -78 deg C, 10 min, 2.) room temp., 3 h; other temp.;
DOI:10.1021/jo00121a019