(S)-benzyl tert-butyl (6-aminohexane-1,5-diyl)dicarbamate

Base Information

• Chemical Name: (S)-benzyl tert-butyl (6-aminohexane-1,5-diyl)dicarbamate
• CAS No.: 318966-47-1
• Molecular Formula: C₁₉H₃₁N₃O₄
• Molecular Weight: 365.473
• Mol file: 318966-47-1.mol

Synonyms:(S)-benzyl tert-butyl (6-aminohexane-1,5-diyl)dicarbamate

Chemical Property of (S)-benzyl tert-butyl (6-aminohexane-1,5-diyl)dicarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-benzyl tert-butyl (6-aminohexane-1,5-diyl)dicarbamate

There total 6 articles about (S)-benzyl tert-butyl (6-aminohexane-1,5-diyl)dicarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(S)-benzyl tert-butyl (6-azidohexane-1,5-diyl)dicarbamate (1401318-32-8) → (S)-benzyl tert-butyl (6-aminohexane-1,5-diyl)dicarbamate (318966-47-1)

Guidance literature:

With thiazolidine-2-thione; 5%-palladium/activated carbon; hydrogen; at 20 ℃; under 25858.1 Torr;

Reference yield: 72.0%

(S)-1-cyano-N--N'--1,5-diaminopentane (175660-26-1) → (S)-benzyl tert-butyl (6-aminohexane-1,5-diyl)dicarbamate (318966-47-1)

Guidance literature:

With ammonia; hydrogen; nickel; In methanol; for 72h; under 5168.35 Torr;

DOI:10.1021/ja0018670

Reference yield:

Z-Lys(Boc)-OH (2389-60-8) → (S)-benzyl tert-butyl (6-aminohexane-1,5-diyl)dicarbamate (318966-47-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 56 percent / ClCO₂Et; Et₃N; NH₃ / tetrahydrofuran / 10 - 20 °C

2: 87 percent / (CF₃CO)2; Et₃N / tetrahydrofuran / 0 °C

3: 72 percent / H₂; NH₃ / Raney-Ni / methanol / 72 h / 5168.35 Torr

With 1,1,1,4,4,4-hexafluoro-2,3-butanedione; ammonia; hydrogen; chloroformic acid ethyl ester; triethylamine; nickel; In tetrahydrofuran; methanol;

DOI:10.1021/ja0018670

upstream raw materials:

(S)-1-cyano-N--N'--1,5-diaminopentane

N-benzyloxycarbonyl-N^ε-tert-butyloxycarbonyl-lysine amide

Z-Lys(Boc)-OH

tert-butyl-N-[(5S)-5-(benzyloxycarbonylamino)-6-hydroxyhexyl]carbamate