tert-butyl 2-(tert-butoxycarbonylamino)-3-(2-bromo-5-(2-(4-methylphenylsulfonyloxy)ethoxy)phenyl)propanoate

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Chemical Name:tert-butyl 2-(tert-butoxycarbonylamino)-3-(2-bromo-5-(2-(4-methylphenylsulfonyloxy)ethoxy)phenyl)propanoate
CAS No.:1571933-87-3
Molecular Formula:C₂₇H₃₆BrNO₈S
Molecular Weight:614.555
Hs Code.:

Synonyms:tert-butyl 2-(tert-butoxycarbonylamino)-3-(2-bromo-5-(2-(4-methylphenylsulfonyloxy)ethoxy)phenyl)propanoate

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Chemical Property of tert-butyl 2-(tert-butoxycarbonylamino)-3-(2-bromo-5-(2-(4-methylphenylsulfonyloxy)ethoxy)phenyl)propanoate

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Technology Process of tert-butyl 2-(tert-butoxycarbonylamino)-3-(2-bromo-5-(2-(4-methylphenylsulfonyloxy)ethoxy)phenyl)propanoate

There total 10 articles about tert-butyl 2-(tert-butoxycarbonylamino)-3-(2-bromo-5-(2-(4-methylphenylsulfonyloxy)ethoxy)phenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 6315-52-2
1,2-bis-tosyloxyethane

: 1571933-84-0
C₁₈H₂₆BrNO₅

: 1571933-87-3
tert-butyl 2-(tert-butoxycarbonylamino)-3-(2-bromo-5-(2-(4-methylphenylsulfonyloxy)ethoxy)phenyl)propanoate

Guidance literature:: With potassium carbonate; In acetone; for 23h; Reflux;

Reference yield: 74.0%

: 1571933-87-3
tert-butyl 2-(tert-butoxycarbonylamino)-3-(2-bromo-5-(2-(4-methylphenylsulfonyloxy)ethoxy)phenyl)propanoate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 48h;

Reference yield:

: 775-06-4,29562-33-2
D/L-3-hydroxy-phenylalanine

: 1571933-87-3
tert-butyl 2-(tert-butoxycarbonylamino)-3-(2-bromo-5-(2-(4-methylphenylsulfonyloxy)ethoxy)phenyl)propanoate

Guidance literature:: Multi-step reaction with 8 steps

1: triethylamine / water; 1,4-dioxane / -2 - 0 °C

2: N,N-dimethylformamide dineopentyl acetal / toluene / 3 h / Reflux

3: 1H-imidazole / N,N-dimethyl-formamide / 2 h / 0 - 20 °C

4: silver trifluoroacetate; iodine / chloroform / 120 h / -60 °C

5: tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium chloride / toluene / 6 h / 100 °C / Inert atmosphere

6: bromine / methanol; diethyl ether / 0.5 h / -70 °C

7: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 °C

8: potassium carbonate / acetone / 23 h / Reflux

With 1H-imidazole; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutyl ammonium fluoride; bromine; iodine; silver trifluoroacetate; potassium carbonate; triethylamine; N,N-dimethylformamide dineopentyl acetal; lithium chloride; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; chloroform; water; N,N-dimethyl-formamide; acetone; toluene;