14-(3-acetoxy-4-methoxyphenyl)-3,10-diacetoxy-2,11,12-trimethoxy-6H-chromeno[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one

Base Information

Chemical Name:14-(3-acetoxy-4-methoxyphenyl)-3,10-diacetoxy-2,11,12-trimethoxy-6H-chromeno[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one
CAS No.:732296-44-5
Molecular Formula:C₃₅H₂₉NO₁₂
Molecular Weight:655.615
Hs Code.:

Synonyms:14-(3-acetoxy-4-methoxyphenyl)-3,10-diacetoxy-2,11,12-trimethoxy-6H-chromeno[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one

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Chemical Property of 14-(3-acetoxy-4-methoxyphenyl)-3,10-diacetoxy-2,11,12-trimethoxy-6H-chromeno[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one

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Technology Process of 14-(3-acetoxy-4-methoxyphenyl)-3,10-diacetoxy-2,11,12-trimethoxy-6H-chromeno[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one

There total 17 articles about 14-(3-acetoxy-4-methoxyphenyl)-3,10-diacetoxy-2,11,12-trimethoxy-6H-chromeno[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 115982-23-5
14-(3-acetoxy-4-methoxyphenyl)-3,10-diacetoxy-2,11,12-trimethoxy-8,9-dihydro-6H-chromeno[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one

: 732296-44-5
14-(3-acetoxy-4-methoxyphenyl)-3,10-diacetoxy-2,11,12-trimethoxy-6H-chromeno[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one

Guidance literature:: With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In 1,2-dichloro-ethane; for 18h; Heating;
DOI:10.1021/jo061810h

Reference yield:

: 121-33-5,8014-42-4
vanillin

: 732296-44-5
14-(3-acetoxy-4-methoxyphenyl)-3,10-diacetoxy-2,11,12-trimethoxy-6H-chromeno[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one

Guidance literature:: Multi-step reaction with 11 steps

1: potassium carbonate / acetone / 6 h / Heating

2: acetic acid; ethylenediamine / 20 °C

3: acetic acid; ethylenediamine / 20 °C

4: lithium aluminium tetrahydride / tetrahydrofuran / 24 h / 20 °C

5: sodium carbonate / dichloromethane; water / 2 h / 20 °C

6: trichlorophosphate / N,N-dimethyl-formamide / 3 h / 20 °C

7: sodium hydrogencarbonate / acetonitrile / 18 h / Heating

8: hydrogen / palladium on activated charcoal / ethyl acetate / 20 °C / 3878.61 Torr

9: sodium hydride / tetrahydrofuran / 0 - 20 °C

10: dmap; triethylamine / dichloromethane / 4 h / 20 °C

11: 2,3-dicyano-5,6-dichloro-p-benzoquinone / 1,2-dichloro-ethane / 18 h / Heating

With dmap; lithium aluminium tetrahydride; hydrogen; sodium hydride; sodium hydrogencarbonate; sodium carbonate; potassium carbonate; acetic acid; ethylenediamine; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; trichlorophosphate; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; water; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetone; acetonitrile; 2: Knoevenagel reaction / 3: Knoevenagel reaction / 6: Bischler-Napieralski reaction;
DOI:10.1021/jo061810h

Reference yield:

: 919082-35-2
ethyl 1-(3-benzyloxy-4-methoxyphenyl)-2-(2,4-dibenzyloxy-5-methoxyphenyl)-7-benzyloxy-8,9-dimethoxy-5,6-dihydropyrrolo[2,1-a]isoquinoline-3-carboxylate

: 732296-44-5
14-(3-acetoxy-4-methoxyphenyl)-3,10-diacetoxy-2,11,12-trimethoxy-6H-chromeno[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / palladium on activated charcoal / ethyl acetate / 20 °C / 3878.61 Torr

2: sodium hydride / tetrahydrofuran / 0 - 20 °C

3: dmap; triethylamine / dichloromethane / 4 h / 20 °C

4: 2,3-dicyano-5,6-dichloro-p-benzoquinone / 1,2-dichloro-ethane / 18 h / Heating

With dmap; hydrogen; sodium hydride; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate; 1,2-dichloro-ethane;
DOI:10.1021/jo061810h