4-{4-[4-(tert-butyl)anilino]-3-fluorophenoxy}-6-methoxy-7-quinolinol

Base Information

• Chemical Name: 4-{4-[4-(tert-butyl)anilino]-3-fluorophenoxy}-6-methoxy-7-quinolinol
• CAS No.: 516526-35-5
• Molecular Formula: C₂₆H₂₅FN₂O₃
• Molecular Weight: 432.495
• Mol file: 516526-35-5.mol

Synonyms:4-{4-[4-(tert-butyl)anilino]-3-fluorophenoxy}-6-methoxy-7-quinolinol

Chemical Property of 4-{4-[4-(tert-butyl)anilino]-3-fluorophenoxy}-6-methoxy-7-quinolinol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-{4-[4-(tert-butyl)anilino]-3-fluorophenoxy}-6-methoxy-7-quinolinol

There total 1 articles about 4-{4-[4-(tert-butyl)anilino]-3-fluorophenoxy}-6-methoxy-7-quinolinol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

N-(4-{[7-(Benzyloxy)-6-methoxy-4-quinolyl]oxy}-2-fluorophenyl)-N-[4-(tert-butyl)phenyl]amine (516526-34-4) → 4-{4-[4-(tert-butyl)anilino]-3-fluorophenoxy}-6-methoxy-7-quinolinol (516526-35-5)

Guidance literature:

With methanesulfonic acid; In trifluoroacetic acid; for 1h; Heating / reflux;

Reference yield: 64.0%

4-(2-chloroethyl)morpholine hydrochride (3647-69-6) + 4-{4-[4-(tert-butyl)anilino]-3-fluorophenoxy}-6-methoxy-7-quinolinol (516526-35-5) → (4-Tert-butylphenyl)-{2-fluoro-4-[6-methoxy-7-(2-morpholin-4-ylethoxy)quinolin-4-yloxy]phenyl}amine

Guidance literature:

With potassium carbonate; In DMF (N,N-dimethyl-formamide); at 80 ℃;

Reference yield:

4-{4-[4-(tert-butyl)anilino]-3-fluorophenoxy}-6-methoxy-7-quinolinol (516526-35-5) → 2-(2-{4-[4-(4-tert-butyl-phenylamino)-3-fluoro-phenoxy]-6-methoxy-quinolin-7-yloxy}-ethylamino)-ethanol

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃ / dimethylformamide

2: K₂CO₃ / dimethylformamide / 80 °C

With potassium carbonate; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2003.12.019

upstream raw materials:

N-(4-{[7-(Benzyloxy)-6-methoxy-4-quinolyl]oxy}-2-fluorophenyl)-N-[4-(tert-butyl)phenyl]amine