(1S,4aR,5S,8aR)-methyl 5-{2-[2-({2-[(3-methoxycarbonyl-1-phenylpropyl)amino]acetylamino}methyl)furan-3-yl]ethyl}-1,4a-dimethyl-6-methylene-decahydronaphthalene-1-carboxylate

Base Information

• Chemical Name: (1S,4aR,5S,8aR)-methyl 5-{2-[2-({2-[(3-methoxycarbonyl-1-phenylpropyl)amino]acetylamino}methyl)furan-3-yl]ethyl}-1,4a-dimethyl-6-methylene-decahydronaphthalene-1-carboxylate
• CAS No.: 1369538-32-8
• Molecular Formula: C₃₄H₄₆N₂O₆
• Molecular Weight: 578.749
• Mol file: 1369538-32-8.mol

Synonyms:(1S,4aR,5S,8aR)-methyl 5-{2-[2-({2-[(3-methoxycarbonyl-1-phenylpropyl)amino]acetylamino}methyl)furan-3-yl]ethyl}-1,4a-dimethyl-6-methylene-decahydronaphthalene-1-carboxylate

Chemical Property of (1S,4aR,5S,8aR)-methyl 5-{2-[2-({2-[(3-methoxycarbonyl-1-phenylpropyl)amino]acetylamino}methyl)furan-3-yl]ethyl}-1,4a-dimethyl-6-methylene-decahydronaphthalene-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,4aR,5S,8aR)-methyl 5-{2-[2-({2-[(3-methoxycarbonyl-1-phenylpropyl)amino]acetylamino}methyl)furan-3-yl]ethyl}-1,4a-dimethyl-6-methylene-decahydronaphthalene-1-carboxylate

There total 4 articles about (1S,4aR,5S,8aR)-methyl 5-{2-[2-({2-[(3-methoxycarbonyl-1-phenylpropyl)amino]acetylamino}methyl)furan-3-yl]ethyl}-1,4a-dimethyl-6-methylene-decahydronaphthalene-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

(1S,4aR,5S,8aR)-methyl 5-(2-{2-[2-(2-chloroacetyl)aminomethyl]furan-3-yl}ethyl)-1,4a-dimethyl-6-methylene-decahydronaphthalene-1-carboxylate (1369538-20-4) + methyl 3-amino-3-phenylpropionate hydrochloride (22838-46-6,88831-43-0,127022-80-4,144494-72-4) → (1S,4aR,5S,8aR)-methyl 5-{2-[2-({2-[(3-methoxycarbonyl-1-phenylpropyl)amino]acetylamino}methyl)furan-3-yl]ethyl}-1,4a-dimethyl-6-methylene-decahydronaphthalene-1-carboxylate (1369538-32-8)

Guidance literature:

With potassium carbonate; In tetrahydrofuran; at 20 ℃; for 6h;

DOI:10.1134/S1068162011060082

Reference yield:

(1S,4aR,5S,8aR)-methyl 5-(2-{2-[(E)-(hydroxyimino)methyl]furan-3-yl}ethyl)-1,4a-dimethyl-6-methylene-decahydronaphthalene-1-carboxylate (1262044-71-2) → (1S,4aR,5S,8aR)-methyl 5-{2-[2-({2-[(3-methoxycarbonyl-1-phenylpropyl)amino]acetylamino}methyl)furan-3-yl]ethyl}-1,4a-dimethyl-6-methylene-decahydronaphthalene-1-carboxylate (1369538-32-8)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogen; sodium hydroxide / ethanol / 5 h / 20 °C

2: triethylamine / dichloromethane / 6 h / 20 °C / Inert atmosphere

3: potassium carbonate / tetrahydrofuran / 6 h / 20 °C

With hydrogen; potassium carbonate; triethylamine; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane;

DOI:10.1134/S1068162011060082

Reference yield:

(1S,4aR,5S,8aR)-methyl 5-{2-[2-(aminomethyl)furan-3-yl]ethyl}-1,4a-dimethyl-6-methylene-decahydronaphthalene-1-carboxylate (1262044-69-8) → (1S,4aR,5S,8aR)-methyl 5-{2-[2-({2-[(3-methoxycarbonyl-1-phenylpropyl)amino]acetylamino}methyl)furan-3-yl]ethyl}-1,4a-dimethyl-6-methylene-decahydronaphthalene-1-carboxylate (1369538-32-8)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 6 h / 20 °C / Inert atmosphere

2: potassium carbonate / tetrahydrofuran / 6 h / 20 °C

With potassium carbonate; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1134/S1068162011060082

upstream raw materials:

(1S,4aR,5S,8aR)-methyl 5-(2-{2-[2-(2-chloroacetyl)aminomethyl]furan-3-yl}ethyl)-1,4a-dimethyl-6-methylene-decahydronaphthalene-1-carboxylate

methyl 3-amino-3-phenylpropionate hydrochloride

(1S,4aR,5S,8aR)-methyl 5-(2-{2-[(E)-(hydroxyimino)methyl]furan-3-yl}ethyl)-1,4a-dimethyl-6-methylene-decahydronaphthalene-1-carboxylate

(1S,4aR,5S,8aR)-methyl 5-{2-[2-(aminomethyl)furan-3-yl]ethyl}-1,4a-dimethyl-6-methylene-decahydronaphthalene-1-carboxylate