3,5,6-TRICHLORO-[1,2,4]TRIAZINE

Base Information

• Chemical Name: 3,5,6-TRICHLORO-[1,2,4]TRIAZINE
• CAS No.: 873-41-6
• Molecular Formula: C3Cl3 N3
• Molecular Weight: 184.412
• Hs Code.: 2933699090
• Mol file: 873-41-6.mol

Synonyms:as-Triazine,3,5,6-trichloro- (6CI,7CI,8CI); 3,5,6-Trichloro-1,2,4-triazine;Trichloro-1,2,4-triazine

Chemical Property of 3,5,6-TRICHLORO-[1,2,4]TRIAZINE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 57-58℃
• Refractive Index: 1.586
• Boiling Point: 337.3ºC at 760 mmHg
• PKA: -2.55±0.63(Predicted)
• Flash Point: 188.209ºC
• PSA: 38.67000
• Density: 1.757g/cm3
• LogP: 1.83180
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

3,5,6-Trichloro-[1,2,4]triazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3,5,6-Trichloro-[1,2,4]triazine (cas# 873-41-6) is a compound useful in organic synthesis.

Technology Process of 3,5,6-TRICHLORO-[1,2,4]TRIAZINE

There total 2 articles about 3,5,6-TRICHLORO-[1,2,4]TRIAZINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.5%

6-bromo-1,2,4-triazine-3,5(2H,4H)-dione (4956-05-2) → 3,5,6-trichlorotriazine (873-41-6)

Guidance literature:

With phosphorus pentachloride; N,N-diethylaniline; trichlorophosphate; at 120 ℃; for 5h;

Reference yield:

→ 3,5,6-trichlorotriazine (873-41-6)

Guidance literature:

5-Brom-6-azauracil, POCl3, PCl5, N,N-Diethylanilin;

Reference yield: 94.0%

3,5,6-trichlorotriazine (873-41-6) + benzylamine (100-46-9) → 3,5-N,N-dibenzylamino-6-chloro-1,2,4-triazine (946403-39-0)

Guidance literature:

In 1,4-dioxane; at 115 ℃; for 5.5h;

upstream raw materials:

6-bromo-1,2,4-triazine-3,5(2H,4H)-dione

Downstream raw materials:

2,6-dichloro-5-pyridylmethyl chloride

5-phenoxy-3,6-dichloro-1,2,4-triazine

5-phenylthio-3,6-dichloro-1,2,4-triazine

5-phenyl-3,6-dichloro-1,2,4-triazine

Refernces

• 1、 Dao, Pascal,Lietha, Daniel,Etheve-Quelquejeu, Mélanie,Garbay, Christiane,Chen, Huixiong. "Synthesis of novel 1,2,4-triazine scaffold as FAK inhibitors with antitumor activity". supporting information. p. 1727 - 1730. Retrieved 2017/04/04.
• 2、 -. "HIV INHIBITING 1,2,4-TRIAZINES". Page 52. . Retrieved 2008/06/13.