(E)-2-((S)-2-Methoxymethyl-pyrrolidin-1-ylmethyl)-1,3-diphenyl-propenone

Base Information

• Chemical Name: (E)-2-((S)-2-Methoxymethyl-pyrrolidin-1-ylmethyl)-1,3-diphenyl-propenone
• CAS No.: 143008-26-8
• Molecular Formula: C₂₂H₂₅NO₂
• Molecular Weight: 335.446
• Mol file: 143008-26-8.mol

Synonyms:(E)-2-((S)-2-Methoxymethyl-pyrrolidin-1-ylmethyl)-1,3-diphenyl-propenone

Chemical Property of (E)-2-((S)-2-Methoxymethyl-pyrrolidin-1-ylmethyl)-1,3-diphenyl-propenone

Chemical Property:

Purity/Quality:

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Technology Process of (E)-2-((S)-2-Methoxymethyl-pyrrolidin-1-ylmethyl)-1,3-diphenyl-propenone

There total 1 articles about (E)-2-((S)-2-Methoxymethyl-pyrrolidin-1-ylmethyl)-1,3-diphenyl-propenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(2S)-2-(methoxymethyl)-1-pyrrolidine (63126-47-6) + (E)-2-nitromethyl-1,3-diphenyl-2-en-1-one (143008-58-6) → (E)-2-((S)-2-Methoxymethyl-pyrrolidin-1-ylmethyl)-1,3-diphenyl-propenone (143008-26-8)

Guidance literature:

In acetonitrile; at 25 ℃; for 1h;

DOI:10.1021/jo00044a026

Reference yield:

lithium di-n-butylcuprate (24406-16-4) + (E)-2-((S)-2-Methoxymethyl-pyrrolidin-1-ylmethyl)-1,3-diphenyl-propenone (143008-26-8) → (S)-2-Methylene-1,3-diphenyl-heptan-1-one (143008-44-0) + (R)-2-Methylene-1,3-diphenyl-heptan-1-one (143008-44-0)

Guidance literature:

With lithium bromide; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts; 1) THF, 25 deg C, 10 min, 2) -90 to 0 deg C, 1 h; or with the corresponding OMOM-derivative;

DOI:10.1021/jo00044a026

upstream raw materials:

(2S)-2-(methoxymethyl)-1-pyrrolidine

(E)-2-nitromethyl-1,3-diphenyl-2-en-1-one

Downstream raw materials:

(S)-2-Methylene-1,3-diphenyl-heptan-1-one

(R)-2-Methylene-1,3-diphenyl-heptan-1-one