N⁶-(3,4,5-Trimethoxy-benzyl)-pyrido[2,3-d]pyrimidine-2,4,6-triamine

Base Information

• Chemical Name: N⁶-(3,4,5-Trimethoxy-benzyl)-pyrido[2,3-d]pyrimidine-2,4,6-triamine
• CAS No.: 175354-66-2
• Molecular Formula: C₁₇H₂₀N₆O₃
• Molecular Weight: 356.384
• Mol file: 175354-66-2.mol

Synonyms:N⁶-(3,4,5-Trimethoxy-benzyl)-pyrido[2,3-d]pyrimidine-2,4,6-triamine

Chemical Property of N⁶-(3,4,5-Trimethoxy-benzyl)-pyrido[2,3-d]pyrimidine-2,4,6-triamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N⁶-(3,4,5-Trimethoxy-benzyl)-pyrido[2,3-d]pyrimidine-2,4,6-triamine

There total 2 articles about N⁶-(3,4,5-Trimethoxy-benzyl)-pyrido[2,3-d]pyrimidine-2,4,6-triamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,4,5-trimethoxy-benzaldehyde (86-81-7) + 2,4,6-triamino-<2,3-d>pyrimidine (175354-65-1) → N6-(3,4,5-Trimethoxy-benzyl)-pyrido[2,3-d]pyrimidine-2,4,6-triamine (175354-66-2)

Guidance literature:

With hydrogen; acetic acid; nickel; In N,N-dimethyl-formamide; for 3.5h; under 1810.02 Torr; Yield given;

DOI:10.1021/jm950786p

Reference yield:

2,4-diamino-6-nitropyrido<2,3-d>pyrimidine (38944-17-1) → N6-(3,4,5-Trimethoxy-benzyl)-pyrido[2,3-d]pyrimidine-2,4,6-triamine (175354-66-2)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / Raney Ni / dimethylformamide / 3 h / 1810.02 Torr

2: AcOH, H₂ / Raney Ni / dimethylformamide / 3.5 h / 1810.02 Torr

With hydrogen; acetic acid; nickel; In N,N-dimethyl-formamide;

DOI:10.1021/jm950786p

Reference yield: 75.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + N6-(3,4,5-Trimethoxy-benzyl)-pyrido[2,3-d]pyrimidine-2,4,6-triamine (175354-66-2) → N6-Methyl-N6-(3,4,5-trimethoxy-benzyl)-pyrido[2,3-d]pyrimidine-2,4,6-triamine

Guidance literature:

With hydrogenchloride; sodium cyanoborohydride; In acetonitrile; for 4h;

DOI:10.1021/jm950786p

upstream raw materials:

3,4,5-trimethoxy-benzaldehyde

2,4,6-triamino-<2,3-d>pyrimidine

2,4-diamino-6-nitropyrido<2,3-d>pyrimidine

Refernces