5'-O-(4,4'-DIMETHOXYTRITYL)-N2-ISOBUTYRYL-2'-DEOXYGUANOSINE-3'-(METHYL-N,N-DIISOPROPYL)PHOSPHORAMIDITE

Base Information

• Chemical Name: 5'-O-(4,4'-DIMETHOXYTRITYL)-N2-ISOBUTYRYL-2'-DEOXYGUANOSINE-3'-(METHYL-N,N-DIISOPROPYL)PHOSPHORAMIDITE
• CAS No.: 84416-84-2
• Molecular Formula: C42H53 N6 O8 P
• Molecular Weight: 800.88
• Mol file: 84416-84-2.mol

Synonyms:5’-O-(4,4’-DIMETHOXYTRITYL)-N2-ISOBUTYRYL-2’-DEOXYGUANOSINE-3’-(METHYL-N,N-DIISOPROPYL)PHOSPHORAMIDITE;5’-O-(4,4’-Dimethoxytrityl)-N2-isobutyryl-2’-deoxyguanosine-3’-(methyl-N,N-diisopropyl)phosphoramidite;dimethoxytrityl-deoxyguanosine phosphoramidite

Chemical Property of 5'-O-(4,4'-DIMETHOXYTRITYL)-N2-ISOBUTYRYL-2'-DEOXYGUANOSINE-3'-(METHYL-N,N-DIISOPROPYL)PHOSPHORAMIDITE

Chemical Property:

• PSA: 164.88000
• LogP: 7.47780
• Storage Temp.: Store at -20°C

Purity/Quality:

97% ^*data from raw suppliers

5'-OXO-(4,4'-DIMETHOXYTRITYL)-N2-ISOBUTYRYL-2'-DEOXYGUANOSINE-3'-(METHYL-N,N-DIISOPROPYL)PHOSPHORAMIDITE 98.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5'-O-(4,4'-DIMETHOXYTRITYL)-N2-ISOBUTYRYL-2'-DEOXYGUANOSINE-3'-(METHYL-N,N-DIISOPROPYL)PHOSPHORAMIDITE

There total 1 articles about 5'-O-(4,4'-DIMETHOXYTRITYL)-N2-ISOBUTYRYL-2'-DEOXYGUANOSINE-3'-(METHYL-N,N-DIISOPROPYL)PHOSPHORAMIDITE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5'-O-dimethoxytrityl-N-isobutyryldeoxyguanosine (68892-41-1) + N,N-diisopropylmethylphosphonamidic chloride (86030-43-5) → [5'-O-(4,4'-dimethoxytrityl)-N2-isobutyryl-2'-deoxyguanosine-3'-yl]-(N,N'-diisopropyl)methylphosphoramidite (84416-84-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; Ambient temperature;

DOI:10.1021/ja00341a078

Reference yield: 91.0%

[5'-O-(4,4'-dimethoxytrityl)-N2-isobutyryl-2'-deoxyguanosine-3'-yl]-(N,N'-diisopropyl)methylphosphoramidite (84416-84-2) → O-(5'-(4,4'-dimethoxytrityl)-2-N-isobutyryl-2'-deoxyguanosin-3'-yl) O-(methyl) H-phosphonothioate

Guidance literature:

With 1H-tetrazole; hydrogen sulfide; In dichloromethane; for 1h;

DOI:10.1016/S0040-4020(99)00241-0

Reference yield:

[5'-O-(4,4'-dimethoxytrityl)-N2-isobutyryl-2'-deoxyguanosine-3'-yl]-(N,N'-diisopropyl)methylphosphoramidite (84416-84-2) + phenol (108-95-2,27073-41-2) → C42H44N5O9P

Guidance literature:

With 1H-tetrazole; In 1,4-dioxane; acetonitrile; at 5 - 20 ℃; for 3.11667h; Molecular sieve; Sonication;

DOI:10.1021/jo202505h

upstream raw materials:

5'-O-dimethoxytrityl-N-isobutyryldeoxyguanosine

N,N-diisopropylmethylphosphonamidic chloride

Downstream raw materials:

methylphenyl N₂-isobutyryl-2'-deoxy-5'-O-dimethoxytritylguanosine-3'-monophosphate

phenyl 2'-deoxyguanosine-3'-monophosphate

phenyl-N₂-isobutyryl-2'-deoxyguanosine-3'-monophosphate

C₄₁H₄₂N₅O₁₀P