2-oxo-3-(4-(4-trifluoromethoxyphenoxy)phenylsulfanyl)propane-1-sulfonic acid dimethyl amide

Base Information

Chemical Name:2-oxo-3-(4-(4-trifluoromethoxyphenoxy)phenylsulfanyl)propane-1-sulfonic acid dimethyl amide
CAS No.:396131-74-1
Molecular Formula:C₁₈H₁₈F₃NO₅S₂
Molecular Weight:449.472
Hs Code.:

Synonyms:2-oxo-3-(4-(4-trifluoromethoxyphenoxy)phenylsulfanyl)propane-1-sulfonic acid dimethyl amide

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Chemical Property of 2-oxo-3-(4-(4-trifluoromethoxyphenoxy)phenylsulfanyl)propane-1-sulfonic acid dimethyl amide

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Technology Process of 2-oxo-3-(4-(4-trifluoromethoxyphenoxy)phenylsulfanyl)propane-1-sulfonic acid dimethyl amide

There total 8 articles about 2-oxo-3-(4-(4-trifluoromethoxyphenoxy)phenylsulfanyl)propane-1-sulfonic acid dimethyl amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 918-05-8
N,N-dimethylmethanesulfonamide

: 361547-22-0
methyl (4-(4-trifluoromethoxyphenoxy)phenylsulfanyl)acetate

: 396131-74-1
2-oxo-3-(4-(4-trifluoromethoxyphenoxy)phenylsulfanyl)propane-1-sulfonic acid dimethyl amide

Guidance literature:: N,N-dimethylmethanesulfonamide; With n-butyllithium; In tetrahydrofuran; hexane; at -25 ℃; for 1.5h;

methyl (4-(4-trifluoromethoxyphenoxy)phenylsulfanyl)acetate; In tetrahydrofuran; hexane; at -78 ℃; for 16h; Further stages.;
DOI:10.1021/jm0103920

Reference yield:

: 828-27-3
4-Trifluoromethoxyphenol

: 396131-74-1
2-oxo-3-(4-(4-trifluoromethoxyphenoxy)phenylsulfanyl)propane-1-sulfonic acid dimethyl amide

Guidance literature:: Multi-step reaction with 7 steps

1.1: t-BuOK / pyridine / 1 h / 100 °C

2.1: H₂ / 10percent Pd/C / methanol / 3 h / 3040.2 Torr

3.1: NaNO₂; aq. HCl / 0.5 h / 0 °C

3.2: aq. HCl / 1 h / 70 °C

4.1: KOH / ethanol / 2 h / 80 °C

5.1: KOH / ethanol / 19 h / 23 - 80 °C

6.1: thionyl chloride / 16 h / 23 °C

7.1: n-BuLi / tetrahydrofuran; hexane / 1.5 h / -25 °C

7.2: 46 percent / tetrahydrofuran; hexane / 16 h / -78 °C

With hydrogenchloride; potassium hydroxide; n-butyllithium; thionyl chloride; potassium tert-butylate; hydrogen; sodium nitrite; 10percent Pd/C; In tetrahydrofuran; pyridine; methanol; ethanol; hexane;
DOI:10.1021/jm0103920

Reference yield:

: 350-46-9,178603-76-4
4-Fluoronitrobenzene

: 396131-74-1
2-oxo-3-(4-(4-trifluoromethoxyphenoxy)phenylsulfanyl)propane-1-sulfonic acid dimethyl amide

Guidance literature:: Multi-step reaction with 7 steps

1.1: t-BuOK / pyridine / 1 h / 100 °C

2.1: H₂ / 10percent Pd/C / methanol / 3 h / 3040.2 Torr

3.1: NaNO₂; aq. HCl / 0.5 h / 0 °C

3.2: aq. HCl / 1 h / 70 °C

4.1: KOH / ethanol / 2 h / 80 °C

5.1: KOH / ethanol / 19 h / 23 - 80 °C

6.1: thionyl chloride / 16 h / 23 °C

7.1: n-BuLi / tetrahydrofuran; hexane / 1.5 h / -25 °C

7.2: 46 percent / tetrahydrofuran; hexane / 16 h / -78 °C

With hydrogenchloride; potassium hydroxide; n-butyllithium; thionyl chloride; potassium tert-butylate; hydrogen; sodium nitrite; 10percent Pd/C; In tetrahydrofuran; pyridine; methanol; ethanol; hexane;
DOI:10.1021/jm0103920