(3aR,4R,7S,7aS)-4-(3-Benzenesulfinyl-propyl)-7-methyl-3a,4,7,7a-tetrahydro-isobenzofuran-1,3-dione

Base Information

• Chemical Name: (3aR,4R,7S,7aS)-4-(3-Benzenesulfinyl-propyl)-7-methyl-3a,4,7,7a-tetrahydro-isobenzofuran-1,3-dione
• CAS No.: 92714-64-2
• Molecular Formula: C₁₈H₂₀O₄S
• Molecular Weight: 332.42
• Mol file: 92714-64-2.mol

Synonyms:(3aR,4R,7S,7aS)-4-(3-Benzenesulfinyl-propyl)-7-methyl-3a,4,7,7a-tetrahydro-isobenzofuran-1,3-dione

Chemical Property of (3aR,4R,7S,7aS)-4-(3-Benzenesulfinyl-propyl)-7-methyl-3a,4,7,7a-tetrahydro-isobenzofuran-1,3-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3aR,4R,7S,7aS)-4-(3-Benzenesulfinyl-propyl)-7-methyl-3a,4,7,7a-tetrahydro-isobenzofuran-1,3-dione

There total 1 articles about (3aR,4R,7S,7aS)-4-(3-Benzenesulfinyl-propyl)-7-methyl-3a,4,7,7a-tetrahydro-isobenzofuran-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

maleic anhydride (108-31-6) + (E,E)-4,6-octadienyl phenyl sulfoxide → (3aR,4R,7S,7aS)-4-(3-Benzenesulfinyl-propyl)-7-methyl-3a,4,7,7a-tetrahydro-isobenzofuran-1,3-dione (92714-64-2)

Guidance literature:

In benzene; at 80 ℃; for 24h;

DOI:10.1021/ja00325a017

Reference yield:

(3aR,4R,7S,7aS)-4-(3-Benzenesulfinyl-propyl)-7-methyl-3a,4,7,7a-tetrahydro-isobenzofuran-1,3-dione (92714-64-2) → (1R,2R,4aS)-7-Benzenesulfinyl-2-methyl-8-oxo-1,2,4a,5,6,7,8,8a-octahydro-naphthalene-1-carboxylic acid

Guidance literature:

With lithium hexamethyldisilazane; In tetrahydrofuran; -78 deg C, 5 d, -40 deg C, 8 h;

DOI:10.1021/ja00325a017

Reference yield:

(3aR,4R,7S,7aS)-4-(3-Benzenesulfinyl-propyl)-7-methyl-3a,4,7,7a-tetrahydro-isobenzofuran-1,3-dione (92714-64-2) → (1R,2R,4aS)-7-Benzenesulfinyl-2-methyl-8-oxo-1,2,4a,5,6,7,8,8a-octahydro-naphthalene-1-carboxylic acid methyl ester

Guidance literature:

Multi-step reaction with 2 steps

1: 1 M lithium bis(trimethylsilyl)amide / tetrahydrofuran / -78 deg C, 5 d, -40 deg C, 8 h

With lithium hexamethyldisilazane; In tetrahydrofuran;

DOI:10.1021/ja00325a017

upstream raw materials:

maleic anhydride

Downstream raw materials:

(+)-Dihydromevinolin

C₂₂H₃₀O₂S₃

C₄₅H₆₀O₅S₃Si

C₄₅H₆₀O₅S₃Si