2-chloro-6-fluoro-N-(3-{[4-(trifluoromethyl)phenyl]amino}[1,2]thiazolo[4,5-b]pyridin-7-yl)benzamide

Base Information

Chemical Name:2-chloro-6-fluoro-N-(3-{[4-(trifluoromethyl)phenyl]amino}[1,2]thiazolo[4,5-b]pyridin-7-yl)benzamide
CAS No.:1427158-58-4
Molecular Formula:C₂₀H₁₁ClF₄N₄OS
Molecular Weight:466.846
Hs Code.:

Synonyms:2-chloro-6-fluoro-N-(3-{[4-(trifluoromethyl)phenyl]amino}[1,2]thiazolo[4,5-b]pyridin-7-yl)benzamide

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Chemical Property of 2-chloro-6-fluoro-N-(3-{[4-(trifluoromethyl)phenyl]amino}[1,2]thiazolo[4,5-b]pyridin-7-yl)benzamide

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Technology Process of 2-chloro-6-fluoro-N-(3-{[4-(trifluoromethyl)phenyl]amino}[1,2]thiazolo[4,5-b]pyridin-7-yl)benzamide

There total 12 articles about 2-chloro-6-fluoro-N-(3-{[4-(trifluoromethyl)phenyl]amino}[1,2]thiazolo[4,5-b]pyridin-7-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₃H₇ClFNO₄

: 1427158-09-5
N³-[4-(trifluoromethyl)phenyl][1,2]thiazolo[4,5-b]pyridine-3,7-diamine

: 1427158-58-4
2-chloro-6-fluoro-N-(3-{[4-(trifluoromethyl)phenyl]amino}[1,2]thiazolo[4,5-b]pyridin-7-yl)benzamide

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 0 - 26 ℃; for 3h;

Reference yield:

: 1427158-10-8
3-bromo-4-chloropyridine-2-carbonitrile

: 1427158-58-4
2-chloro-6-fluoro-N-(3-{[4-(trifluoromethyl)phenyl]amino}[1,2]thiazolo[4,5-b]pyridin-7-yl)benzamide

Guidance literature:: Multi-step reaction with 6 steps

1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 70 °C

2: 1-methyl-pyrrolidin-2-one; sodium thiomethoxide / 1 h / 130 - 140 °C

3: bromine / ethyl acetate / 2.5 h / 0 - 26 °C / Reflux

4: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 2 h / 110 °C / Inert atmosphere

5: trifluoroacetic acid / 2 h / 80 °C

6: sodium hydride / tetrahydrofuran / 3 h / 0 - 26 °C

With 1-methyl-pyrrolidin-2-one; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; bromine; sodium hydride; caesium carbonate; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; sodium thiomethoxide; In tetrahydrofuran; 1,4-dioxane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1427158-13-1
4-[(4-methoxybenzyl)amino]-3-sulfanylpyridine-2-carbonitrile

: 1427158-58-4
2-chloro-6-fluoro-N-(3-{[4-(trifluoromethyl)phenyl]amino}[1,2]thiazolo[4,5-b]pyridin-7-yl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: bromine / ethyl acetate / 2.5 h / 0 - 26 °C / Reflux

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 2 h / 110 °C / Inert atmosphere

3: trifluoroacetic acid / 2 h / 80 °C

4: sodium hydride / tetrahydrofuran / 3 h / 0 - 26 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; bromine; sodium hydride; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; ethyl acetate;