10-bromo-3-phenyl-6,7-dihydro-1H-pyrimido[6,1-a]isoquinoline-2,4(3H,11bH)-dione

Base Information

Chemical Name:10-bromo-3-phenyl-6,7-dihydro-1H-pyrimido[6,1-a]isoquinoline-2,4(3H,11bH)-dione
CAS No.:1325226-76-3
Molecular Formula:C₁₈H₁₅BrN₂O₂
Molecular Weight:371.233
Hs Code.:

Synonyms:10-bromo-3-phenyl-6,7-dihydro-1H-pyrimido[6,1-a]isoquinoline-2,4(3H,11bH)-dione

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Chemical Property of 10-bromo-3-phenyl-6,7-dihydro-1H-pyrimido[6,1-a]isoquinoline-2,4(3H,11bH)-dione

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Technology Process of 10-bromo-3-phenyl-6,7-dihydro-1H-pyrimido[6,1-a]isoquinoline-2,4(3H,11bH)-dione

There total 1 articles about 10-bromo-3-phenyl-6,7-dihydro-1H-pyrimido[6,1-a]isoquinoline-2,4(3H,11bH)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 17680-54-5
7-bromo-3,4-dihydroisoquinoline

: 111061-31-5
1-phenoxy-1-trimethylsilyloxyethene

: 103-71-9
phenyl isocyanate

: 1325226-76-3
10-bromo-3-phenyl-6,7-dihydro-1H-pyrimido[6,1-a]isoquinoline-2,4(3H,11bH)-dione

Guidance literature:: 7-bromo-3,4-dihydroisoquinoline; 1-phenoxy-1-trimethylsilyloxyethene; With trimethylsilyl trifluoromethanesulfonate; In 1,2-dimethoxyethane; at -40 ℃; for 14h; Inert atmosphere;

phenyl isocyanate; In 1,2-dimethoxyethane; at -40 - 20 ℃; for 2h; Inert atmosphere;
DOI:10.1021/ol201739u

Reference yield: 92.0%

: 98437-24-2
benzofuran-2-boronic acid

: 1325226-76-3
10-bromo-3-phenyl-6,7-dihydro-1H-pyrimido[6,1-a]isoquinoline-2,4(3H,11bH)-dione

: 1325226-77-4
10-(benzofuran-2-yl)-3-phenyl-6,7-dihydro-1H-pyrimido[6,1-a]isoquinoline-2,4(3H,11bH)-dione

Guidance literature:: With bis(tri-t-butylphosphine)palladium⁽⁰⁾; caesium carbonate; In toluene; at 90 ℃; for 3h; Inert atmosphere;
DOI:10.1021/ol201739u