7-(4-fluoro-phenyl)-6-(2-methanesulfinyl-pyrimidin-4-yl)-2,3-dihydro-pyrazolo[5,1-b]oxazole

Base Information

Chemical Name:7-(4-fluoro-phenyl)-6-(2-methanesulfinyl-pyrimidin-4-yl)-2,3-dihydro-pyrazolo[5,1-b]oxazole
CAS No.:761000-11-7
Molecular Formula:C₁₆H₁₃FN₄O₂S
Molecular Weight:344.369
Hs Code.:

7-(4-fluoro-phenyl)-6-(2-methanesulfinyl-pyrimidin-4-yl)-2,3-dihydro-pyrazolo[5,1-<i>b</i>]oxazole

Synonyms:7-(4-fluoro-phenyl)-6-(2-methanesulfinyl-pyrimidin-4-yl)-2,3-dihydro-pyrazolo[5,1-b]oxazole

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Chemical Property of 7-(4-fluoro-phenyl)-6-(2-methanesulfinyl-pyrimidin-4-yl)-2,3-dihydro-pyrazolo[5,1-b]oxazole

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Technology Process of 7-(4-fluoro-phenyl)-6-(2-methanesulfinyl-pyrimidin-4-yl)-2,3-dihydro-pyrazolo[5,1-b]oxazole

There total 5 articles about 7-(4-fluoro-phenyl)-6-(2-methanesulfinyl-pyrimidin-4-yl)-2,3-dihydro-pyrazolo[5,1-b]oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 761000-09-3
7-(4-fluoro-phenyl)-6-(2-methylsulfanyl-pyrimidin-4-yl)-2,3-dihydro-pyrazolo[5,1-b]oxazole

: 761000-11-7
7-(4-fluoro-phenyl)-6-(2-methanesulfinyl-pyrimidin-4-yl)-2,3-dihydro-pyrazolo[5,1-b]oxazole

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In chloroform; at 0 ℃;
DOI:10.1016/j.bmcl.2004.07.024

Reference yield:

: 34837-84-8
4-fluorobenzeneacetic acid methyl ester

: 761000-11-7
7-(4-fluoro-phenyl)-6-(2-methanesulfinyl-pyrimidin-4-yl)-2,3-dihydro-pyrazolo[5,1-b]oxazole

Guidance literature:: Multi-step reaction with 5 steps

1: 76 percent / LDA / tetrahydrofuran / -78 °C

2: 43 percent / CrO₃; pyridine / CH₂Cl₂

3: 81 percent / semicarbazide hydrochloride / ethanol / 78 °C

4: 44 percent / NaH / dimethylformamide / 20 °C

5: 100 percent / mCPBA / CHCl₃ / 0 °C

With pyridine; chromium(VI) oxide; semicarbazide hydrochloride; sodium hydride; 3-chloro-benzenecarboperoxoic acid; lithium diisopropyl amide; In tetrahydrofuran; ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2004.07.024

Reference yield:

: 1074-68-6
4-formyl-2-(methylthio)pyrimidine

: 761000-11-7
7-(4-fluoro-phenyl)-6-(2-methanesulfinyl-pyrimidin-4-yl)-2,3-dihydro-pyrazolo[5,1-b]oxazole

Guidance literature:: Multi-step reaction with 5 steps

1: 76 percent / LDA / tetrahydrofuran / -78 °C

2: 43 percent / CrO₃; pyridine / CH₂Cl₂

3: 81 percent / semicarbazide hydrochloride / ethanol / 78 °C

4: 44 percent / NaH / dimethylformamide / 20 °C

5: 100 percent / mCPBA / CHCl₃ / 0 °C

With pyridine; chromium(VI) oxide; semicarbazide hydrochloride; sodium hydride; 3-chloro-benzenecarboperoxoic acid; lithium diisopropyl amide; In tetrahydrofuran; ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2004.07.024