(3R)-8-[1-(4-methyl-benzyl)-1H-[1,2,3]triazol-4-yl]-7-naphthalen-1-ylmethyl-5-oxo-2,3-dihydro-5H-thiazolo[3,2-a]pyridine-3-carboxylic acid

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Chemical Name:(3R)-8-[1-(4-methyl-benzyl)-1H-[1,2,3]triazol-4-yl]-7-naphthalen-1-ylmethyl-5-oxo-2,3-dihydro-5H-thiazolo[3,2-a]pyridine-3-carboxylic acid
CAS No.:1394135-83-1
Molecular Formula:C₂₉H₂₄N₄O₃S
Molecular Weight:508.601
Hs Code.:

Synonyms:(3R)-8-[1-(4-methyl-benzyl)-1H-[1,2,3]triazol-4-yl]-7-naphthalen-1-ylmethyl-5-oxo-2,3-dihydro-5H-thiazolo[3,2-a]pyridine-3-carboxylic acid

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Chemical Property of (3R)-8-[1-(4-methyl-benzyl)-1H-[1,2,3]triazol-4-yl]-7-naphthalen-1-ylmethyl-5-oxo-2,3-dihydro-5H-thiazolo[3,2-a]pyridine-3-carboxylic acid

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Technology Process of (3R)-8-[1-(4-methyl-benzyl)-1H-[1,2,3]triazol-4-yl]-7-naphthalen-1-ylmethyl-5-oxo-2,3-dihydro-5H-thiazolo[3,2-a]pyridine-3-carboxylic acid

There total 6 articles about (3R)-8-[1-(4-methyl-benzyl)-1H-[1,2,3]triazol-4-yl]-7-naphthalen-1-ylmethyl-5-oxo-2,3-dihydro-5H-thiazolo[3,2-a]pyridine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1394135-70-6
(3R)-6-bromo-8-[1-(4-methyl-benzyl)-1H-[1,2,3]triazol-4-yl]-7-naphthalen-1-ylmethyl-5-oxo-2,3-dihydro-5H-thiazolo[3,2-a]pyridine-3-carboxylic acid

: 1394135-83-1
(3R)-8-[1-(4-methyl-benzyl)-1H-[1,2,3]triazol-4-yl]-7-naphthalen-1-ylmethyl-5-oxo-2,3-dihydro-5H-thiazolo[3,2-a]pyridine-3-carboxylic acid

Guidance literature:: With palladium 10% on activated carbon; ammonium formate; In methanol; for 4h; Reflux;
DOI:10.1016/j.ejmech.2012.06.018

Reference yield:

: 1394135-49-9
(3R)-6-bromo-7-naphthalen-1-ylmethyl-5-oxo-8-ethynyl-2,3-dihydro-5H-thiazolo[3,2-a]pyridine-3-carboxylic acid methyl ester

: 1394135-83-1
(3R)-8-[1-(4-methyl-benzyl)-1H-[1,2,3]triazol-4-yl]-7-naphthalen-1-ylmethyl-5-oxo-2,3-dihydro-5H-thiazolo[3,2-a]pyridine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium azide; copper(II) sulfate; sodium L-ascorbate / water; N,N-dimethyl-formamide / 16 h / 70 °C

2.1: lithium hydroxide / tetrahydrofuran; water / 17 h / 20 °C

2.2: pH 1

3.1: palladium 10% on activated carbon; ammonium formate / methanol / 4 h / Reflux

With sodium azide; palladium 10% on activated carbon; ammonium formate; copper(II) sulfate; sodium L-ascorbate; lithium hydroxide; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2012.06.018

Reference yield:

: C₂₅H₂₄BrNO₃SSi

: 1394135-83-1
(3R)-8-[1-(4-methyl-benzyl)-1H-[1,2,3]triazol-4-yl]-7-naphthalen-1-ylmethyl-5-oxo-2,3-dihydro-5H-thiazolo[3,2-a]pyridine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: methanol; potassium carbonate / tetrahydrofuran / 0.25 h / 20 °C

2.1: sodium azide; copper(II) sulfate; sodium L-ascorbate / water; N,N-dimethyl-formamide / 16 h / 70 °C

3.1: lithium hydroxide / tetrahydrofuran; water / 17 h / 20 °C

3.2: pH 1

4.1: palladium 10% on activated carbon; ammonium formate / methanol / 4 h / Reflux

With methanol; sodium azide; palladium 10% on activated carbon; ammonium formate; potassium carbonate; copper(II) sulfate; sodium L-ascorbate; lithium hydroxide; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2012.06.018