tert-butyl 2-[2-methoxy-4-(7-methoxy-1,6-naphthyridin-4-yloxy)phenyl]acetate

Base Information

Chemical Name:tert-butyl 2-[2-methoxy-4-(7-methoxy-1,6-naphthyridin-4-yloxy)phenyl]acetate
CAS No.:952138-20-4
Molecular Formula:C₂₂H₂₄N₂O₅
Molecular Weight:396.443
Hs Code.:

Synonyms:tert-butyl 2-[2-methoxy-4-(7-methoxy-1,6-naphthyridin-4-yloxy)phenyl]acetate

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Chemical Property of tert-butyl 2-[2-methoxy-4-(7-methoxy-1,6-naphthyridin-4-yloxy)phenyl]acetate

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Technology Process of tert-butyl 2-[2-methoxy-4-(7-methoxy-1,6-naphthyridin-4-yloxy)phenyl]acetate

There total 11 articles about tert-butyl 2-[2-methoxy-4-(7-methoxy-1,6-naphthyridin-4-yloxy)phenyl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 948571-52-6
tert-butyl 2-(4-hydroxy-2-methoxyphenyl)acetate

: 952138-19-1
4-chloro-7-methoxy-[1,6]naphthyridine

: 952138-20-4
tert-butyl 2-[2-methoxy-4-(7-methoxy-1,6-naphthyridin-4-yloxy)phenyl]acetate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 70 ℃; for 2.5h;

Reference yield:

: 20265-39-8
4-amino-2-methoxypyridine

: 952138-20-4
tert-butyl 2-[2-methoxy-4-(7-methoxy-1,6-naphthyridin-4-yloxy)phenyl]acetate

Guidance literature:: Multi-step reaction with 6 steps

1: N-Bromosuccinimide / acetonitrile / 10 °C

2: isopropyl alcohol / 0.75 h / 20 - 75 °C

3: diphenylether; biphenyl / 0.08 h / 120 - 250 °C

4: ammonium formate / 5% palladium over charcoal / methanol / 4 h / Heating / reflux

5: N-ethyl-N,N-diisopropylamine; trichlorophosphate / para-dichlorobenzene / 1.5 h / 10 - 70 °C

6: caesium carbonate / N,N-dimethyl-formamide / 2.5 h / 70 °C

With N-Bromosuccinimide; ammonium formate; caesium carbonate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; 5% palladium over charcoal; In methanol; diphenylether; biphenyl; para-dichlorobenzene; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;

Reference yield:

: 215364-86-6
3-bromo-2-methoxypyridin-4-ylamine

: 952138-20-4
tert-butyl 2-[2-methoxy-4-(7-methoxy-1,6-naphthyridin-4-yloxy)phenyl]acetate

Guidance literature:: Multi-step reaction with 5 steps

1: isopropyl alcohol / 0.75 h / 20 - 75 °C

2: diphenylether; biphenyl / 0.08 h / 120 - 250 °C

3: ammonium formate / 5% palladium over charcoal / methanol / 4 h / Heating / reflux

4: N-ethyl-N,N-diisopropylamine; trichlorophosphate / para-dichlorobenzene / 1.5 h / 10 - 70 °C

5: caesium carbonate / N,N-dimethyl-formamide / 2.5 h / 70 °C

With ammonium formate; caesium carbonate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; 5% palladium over charcoal; In methanol; diphenylether; biphenyl; para-dichlorobenzene; N,N-dimethyl-formamide; isopropyl alcohol;