PHENYL-METHIONINE-D-ARGININE-PHENYL AMIDE)

Base Information

• Chemical Name: PHENYL-METHIONINE-D-ARGININE-PHENYL AMIDE)
• CAS No.: 84313-44-0
• Molecular Formula: C₂₉H₄₂N₈O₄S
• Molecular Weight: 598.77
• Mol file: 84313-44-0.mol

Synonyms:PHENYL-METHIONINE-D-ARGININE-PHENYL AMIDE);H-Phe-Met-D-Arg-Phe-NH2;neuropeptide C [D-Arg3];[D-Arg3]-Molluscan cardioexcitatory neuropeptide;Phe-Met-D-Arg-Phe amide

Chemical Property of PHENYL-METHIONINE-D-ARGININE-PHENYL AMIDE)

Chemical Property:

• PSA: 243.61000
• LogP: 3.51940
• Storage Temp.: −20°C

Purity/Quality:

98.5% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of PHENYL-METHIONINE-D-ARGININE-PHENYL AMIDE)

There total 14 articles about PHENYL-METHIONINE-D-ARGININE-PHENYL AMIDE) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

L-Phenylalanine amide (5241-58-7) + H-Phe-Met-Arg-OH (123197-18-2) → Neuropeptide C (64190-70-1,84313-42-8,84413-35-4,84313-44-0)

Guidance literature:

With thermolysin; In methanol; for 3h; Product distribution; Ambient temperature; effect of the pH, conc. of MeOH, reaction time;

DOI:10.1248/cpb.36.4345

Reference yield: 67.0%

Boc-Phe-Met-Arg(Mts)-Phe-NH2 (123197-28-4) → Neuropeptide C (64190-70-1,84313-42-8,84413-35-4,84313-44-0)

Guidance literature:

With ethandithiol; trifluorormethanesulfonic acid; methyl-phenyl-thioether; In trifluoroacetic acid; for 1h;

DOI:10.1248/cpb.36.4345

Reference yield:

N-tert-butoxycarbonyl-L-phenylalanine (13734-34-4) → Neuropeptide C (64190-70-1,84313-42-8,84413-35-4,84313-44-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 61 percent / N-methylmorpholine / dimethylformamide; tetrahydrofuran / 3 h

2: 89 percent / N-methylmorpholine, HOBt, DCC / dimethylformamide / 16 h

3: 67 percent / TFMSA-thioanisole, ethanedithiol / trifluoroacetic acid / 1 h

With 4-methyl-morpholine; ethandithiol; trifluorormethanesulfonic acid; methyl-phenyl-thioether; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; N,N-dimethyl-formamide; trifluoroacetic acid;

DOI:10.1248/cpb.36.4345

upstream raw materials:

L-Phenylalanine amide

H-Phe-Met-Arg-OH

Boc-Phe-Met-Arg(Mts)-Phe-NH₂

N-benzoxycarbonyl-L-phenylalanyl-L-methionyl-N-^γ-nitro-L-arginyl-L-phenylalaninamide