4-{3-[4-(2-piperidin-1-ylethoxy)phenyl]pyrrolo[1,2-a]pyrimidin-8-yl}quinoline

Base Information

Chemical Name:4-{3-[4-(2-piperidin-1-ylethoxy)phenyl]pyrrolo[1,2-a]pyrimidin-8-yl}quinoline
CAS No.:1062368-35-7
Molecular Formula:C₂₉H₂₈N₄O
Molecular Weight:448.568
Hs Code.:

Synonyms:4-{3-[4-(2-piperidin-1-ylethoxy)phenyl]pyrrolo[1,2-a]pyrimidin-8-yl}quinoline

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Chemical Property of 4-{3-[4-(2-piperidin-1-ylethoxy)phenyl]pyrrolo[1,2-a]pyrimidin-8-yl}quinoline

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Technology Process of 4-{3-[4-(2-piperidin-1-ylethoxy)phenyl]pyrrolo[1,2-a]pyrimidin-8-yl}quinoline

There total 4 articles about 4-{3-[4-(2-piperidin-1-ylethoxy)phenyl]pyrrolo[1,2-a]pyrimidin-8-yl}quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1062368-34-6
4-(8-quinolin-4-yl-pyrrolo[1,2-a]pyrimidin-3-yl)-phenol

: 2008-75-5
N-chloroethylpiperidine hydrochloride

: 1062368-35-7
4-{3-[4-(2-piperidin-1-ylethoxy)phenyl]pyrrolo[1,2-a]pyrimidin-8-yl}quinoline

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 24h;
DOI:10.1016/j.bmcl.2008.06.052

Reference yield:

: 1062368-30-2
methyl 5-nitro-4-quinolin-4-yl-1H-pyrrole-2-carboxylate

: 1062368-35-7
4-{3-[4-(2-piperidin-1-ylethoxy)phenyl]pyrrolo[1,2-a]pyrimidin-8-yl}quinoline

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / 5%-palladium/activated carbon / methanol / 0.67 h

2.1: acetic acid / methanol / 82 °C

2.2: 20 °C / Saturated solution

3.1: sulfuric acid; water / 0 - 110 °C

3.2: 20 °C / Saturated solution

4.1: sodium hydride / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere

With sulfuric acid; water; hydrogen; sodium hydride; acetic acid; 5%-palladium/activated carbon; In methanol; N,N-dimethyl-formamide;

Reference yield:

: 1062368-31-3
C₁₅H₁₃N₃O₂

: 1062368-35-7
4-{3-[4-(2-piperidin-1-ylethoxy)phenyl]pyrrolo[1,2-a]pyrimidin-8-yl}quinoline

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid / methanol / 82 °C

1.2: 20 °C / Saturated solution

2.1: sulfuric acid; water / 0 - 110 °C

2.2: 20 °C / Saturated solution

3.1: sodium hydride / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere

With sulfuric acid; water; sodium hydride; acetic acid; In methanol; N,N-dimethyl-formamide;