(R,R)-N-{3-[5-amino-6-fluoro-3-methyl-6-(trifluoromethyl)-3,6-dihydro-2H-1,4-oxazin-3-yl]phenyl}-5-chloropyridine-2-carboxamide

Base Information

Chemical Name:(R*,R*)-N-{3-[5-amino-6-fluoro-3-methyl-6-(trifluoromethyl)-3,6-dihydro-2H-1,4-oxazin-3-yl]phenyl}-5-chloropyridine-2-carboxamide
CAS No.:1352431-63-0
Molecular Formula:C₁₈H₁₅ClF₄N₄O₂
Molecular Weight:430.789
Hs Code.:

Synonyms:(R*,R*)-N-{3-[5-amino-6-fluoro-3-methyl-6-(trifluoromethyl)-3,6-dihydro-2H-1,4-oxazin-3-yl]phenyl}-5-chloropyridine-2-carboxamide

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Chemical Property of (R*,R*)-N-{3-[5-amino-6-fluoro-3-methyl-6-(trifluoromethyl)-3,6-dihydro-2H-1,4-oxazin-3-yl]phenyl}-5-chloropyridine-2-carboxamide

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Technology Process of (R*,R*)-N-{3-[5-amino-6-fluoro-3-methyl-6-(trifluoromethyl)-3,6-dihydro-2H-1,4-oxazin-3-yl]phenyl}-5-chloropyridine-2-carboxamide

There total 10 articles about (R*,R*)-N-{3-[5-amino-6-fluoro-3-methyl-6-(trifluoromethyl)-3,6-dihydro-2H-1,4-oxazin-3-yl]phenyl}-5-chloropyridine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: rac-N-{3-[5-amino-6-fluoro-3-methyl-6-(trifluoromethyl)-3,6-dihydro-2H-1,4-oxazin-3-yl]phenyl}-5-chloropyridine-2-carboxamide

: 1352431-63-0
(R*,R*)-N-{3-[5-amino-6-fluoro-3-methyl-6-(trifluoromethyl)-3,6-dihydro-2H-1,4-oxazin-3-yl]phenyl}-5-chloropyridine-2-carboxamide

: 1352431-65-2
(S*,S*)-N-{3-[5-amino-6-fluoro-3-methyl-6-(trifluoromethyl)-3,6-dihydro-2H-1,4-oxazin-3-yl]phenyl}-5-chloropyridine-2-carboxamide

Guidance literature:: With Chiralpak Daicel OD; In carbon dioxide; isopropylamine; isopropyl alcohol; Resolution of racemate;

Reference yield:

: 2142-63-4
1-(3-Bromophenyl)ethanone

: 1352431-63-0
(R*,R*)-N-{3-[5-amino-6-fluoro-3-methyl-6-(trifluoromethyl)-3,6-dihydro-2H-1,4-oxazin-3-yl]phenyl}-5-chloropyridine-2-carboxamide

: 1352431-65-2
(S*,S*)-N-{3-[5-amino-6-fluoro-3-methyl-6-(trifluoromethyl)-3,6-dihydro-2H-1,4-oxazin-3-yl]phenyl}-5-chloropyridine-2-carboxamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: ammonium chloride / ammonia; methanol / 96 h / 20 °C

2.1: hydrogenchloride / 96 h / Reflux

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / -15 - 0 °C

4.1: Chiralpak_.(R). Daicel / carbon dioxide; methanol / Resolution of racemate

5.1: di-isopropyl ether / 0 - 70 °C

6.1: diethylamino-sulfur trifluoride / dichloromethane / 0.5 h / 0 °C

7.1: Lawessons reagent / toluene / -78 - 20 °C

8.1: ammonium hydroxide / ethanol / 48 h / 40 °C

9.1: (1R,2R)-1,2-diaminocyclohexane; potassium phosphate; copper(l) iodide / N,N-dimethyl-formamide / 2.25 h / 180 °C / Sealed tube; Inert atmosphere; Microwave irradiation

9.2: 1 h / 20 °C

10.1: Chiralpak_.(R). Daicel OD / isopropyl alcohol; carbon dioxide; isopropylamine / Resolution of racemate

With Lawessons reagent; hydrogenchloride; ammonium hydroxide; potassium phosphate; copper(l) iodide; lithium aluminium tetrahydride; diethylamino-sulfur trifluoride; (1R,2R)-1,2-diaminocyclohexane; ammonium chloride; In tetrahydrofuran; methanol; ethanol; dichloromethane; di-isopropyl ether; carbon dioxide; ammonia; isopropylamine; N,N-dimethyl-formamide; isopropyl alcohol; toluene;

Reference yield:

: 953741-63-4
rac-2-amino-2-(3-bromo-phenyl)-propionitrile

: 1352431-63-0
(R*,R*)-N-{3-[5-amino-6-fluoro-3-methyl-6-(trifluoromethyl)-3,6-dihydro-2H-1,4-oxazin-3-yl]phenyl}-5-chloropyridine-2-carboxamide

: 1352431-65-2
(S*,S*)-N-{3-[5-amino-6-fluoro-3-methyl-6-(trifluoromethyl)-3,6-dihydro-2H-1,4-oxazin-3-yl]phenyl}-5-chloropyridine-2-carboxamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: hydrogenchloride / 96 h / Reflux

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / -15 - 0 °C

3.1: Chiralpak_.(R). Daicel / carbon dioxide; methanol / Resolution of racemate

4.1: di-isopropyl ether / 0 - 70 °C

5.1: diethylamino-sulfur trifluoride / dichloromethane / 0.5 h / 0 °C

6.1: Lawessons reagent / toluene / -78 - 20 °C

7.1: ammonium hydroxide / ethanol / 48 h / 40 °C

8.1: (1R,2R)-1,2-diaminocyclohexane; potassium phosphate; copper(l) iodide / N,N-dimethyl-formamide / 2.25 h / 180 °C / Sealed tube; Inert atmosphere; Microwave irradiation

8.2: 1 h / 20 °C

9.1: Chiralpak_.(R). Daicel OD / isopropyl alcohol; carbon dioxide; isopropylamine / Resolution of racemate

With Lawessons reagent; hydrogenchloride; ammonium hydroxide; potassium phosphate; copper(l) iodide; lithium aluminium tetrahydride; diethylamino-sulfur trifluoride; (1R,2R)-1,2-diaminocyclohexane; In tetrahydrofuran; methanol; ethanol; dichloromethane; di-isopropyl ether; carbon dioxide; isopropylamine; N,N-dimethyl-formamide; isopropyl alcohol; toluene;