2-[(1R,2R,4S,5S)-2-(tert-Butyl-dimethyl-silanyloxy)-5-isopropenyl-4-methyl-4-vinyl-cyclohexyl]-ethanol

Base Information

Chemical Name:2-[(1R,2R,4S,5S)-2-(tert-Butyl-dimethyl-silanyloxy)-5-isopropenyl-4-methyl-4-vinyl-cyclohexyl]-ethanol
CAS No.:561063-86-3
Molecular Formula:C₂₀H₃₈O₂Si
Molecular Weight:338.606
Hs Code.:

Synonyms:2-[(1R,2R,4S,5S)-2-(tert-Butyl-dimethyl-silanyloxy)-5-isopropenyl-4-methyl-4-vinyl-cyclohexyl]-ethanol

Suppliers and Price of 2-[(1R,2R,4S,5S)-2-(tert-Butyl-dimethyl-silanyloxy)-5-isopropenyl-4-methyl-4-vinyl-cyclohexyl]-ethanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-[(1R,2R,4S,5S)-2-(tert-Butyl-dimethyl-silanyloxy)-5-isopropenyl-4-methyl-4-vinyl-cyclohexyl]-ethanol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-[(1R,2R,4S,5S)-2-(tert-Butyl-dimethyl-silanyloxy)-5-isopropenyl-4-methyl-4-vinyl-cyclohexyl]-ethanol

There total 23 articles about 2-[(1R,2R,4S,5S)-2-(tert-Butyl-dimethyl-silanyloxy)-5-isopropenyl-4-methyl-4-vinyl-cyclohexyl]-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 561063-77-2
[(1R,2R,4S,5S)-2-(2-Benzyloxy-ethyl)-4-isopropenyl-5-methyl-5-vinyl-cyclohexyloxy]-tert-butyl-dimethyl-silane

: 561063-86-3
2-[(1R,2R,4S,5S)-2-(tert-Butyl-dimethyl-silanyloxy)-5-isopropenyl-4-methyl-4-vinyl-cyclohexyl]-ethanol

Guidance literature:: With ammonia; sodium; In tetrahydrofuran; at -78 ℃;

Reference yield:

: 128355-20-4
(3R,4S)-3-tert-butyloxycarbonylmethyl-4-hydroxy-5-tetrahydropyranyloxypentanoic acid γ-lactone

: 561063-86-3
2-[(1R,2R,4S,5S)-2-(tert-Butyl-dimethyl-silanyloxy)-5-isopropenyl-4-methyl-4-vinyl-cyclohexyl]-ethanol

Guidance literature:: Multi-step reaction with 23 steps

1.1: 87 percent / DIBALH / tetrahydrofuran / -78 °C

2.1: 99 percent / (+/-)-CSA / 50 °C

3.1: Et₃N; DMAP / dimethylformamide / 0 - 20 °C

4.1: LiAlH₄ / diethyl ether / 0 - 20 °C

5.1: NaH / tetrahydrofuran; dimethylformamide / 0 - 20 °C

6.1: TBAF / tetrahydrofuran / 20 °C

7.1: Et₃N / CH₂Cl₂ / 0 °C

8.1: NaI / acetone / Heating

9.1: BuLi / tetrahydrofuran / -78 - 20 °C

9.2: tetrahydrofuran / -78 - 20 °C

10.1: (+/-)-CSA / methanol; H₂O / 60 °C

11.1: 72 percent / diethyl ether / -78 °C

12.1: aq. AcOH / 60 °C

13.1: 1,2-dichloro-ethane / 80 °C

14.1: 68 percent / Et₃N; DMAP / dimethylformamide / 40 °C

15.1: 87 percent / PDC; 4 Angstroem molecular sieves / CH₂Cl₂ / 20 °C

16.1: 81 percent / NaBH₄ / methanol / 0 °C

17.1: CBr₄; Ph₃P / CH₂Cl₂ / 20 °C

18.1: 55 percent / SmI₂ / tetrahydrofuran; hexamethylphosphoric acid triamide / 20 °C

19.1: 78 percent / DIBALH / diethyl ether / -78 °C

20.1: Bu₃P; pyridine / 20 °C

21.1: MCPBA / CH₂Cl₂

22.1: i-Pr₂NEt / 1,2-dichloro-benzene / 160 °C

23.1: 95 percent / Na; NH₃ / tetrahydrofuran / -78 °C

With pyridine; dmap; sodium tetrahydroborate; lithium aluminium tetrahydride; dipyridinium dichromate; n-butyllithium; samarium diiodide; carbon tetrabromide; tributylphosphine; 4 A molecular sieve; 10-camphorsufonic acid; tetrabutyl ammonium fluoride; ammonia; sodium; sodium hydride; diisobutylaluminium hydride; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; sodium iodide; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; 1,2-dichloro-benzene; acetone; 13.1: Wittig reaction;

Reference yield:

: 561063-79-4
[(2S,3R)-5-Hydroxy-2-(tetrahydro-pyran-2-yloxymethyl)-tetrahydro-furan-3-yl]-acetic acid tert-butyl ester

: 561063-86-3
2-[(1R,2R,4S,5S)-2-(tert-Butyl-dimethyl-silanyloxy)-5-isopropenyl-4-methyl-4-vinyl-cyclohexyl]-ethanol

Guidance literature:: Multi-step reaction with 22 steps

1.1: 99 percent / (+/-)-CSA / 50 °C

2.1: Et₃N; DMAP / dimethylformamide / 0 - 20 °C

3.1: LiAlH₄ / diethyl ether / 0 - 20 °C

4.1: NaH / tetrahydrofuran; dimethylformamide / 0 - 20 °C

5.1: TBAF / tetrahydrofuran / 20 °C

6.1: Et₃N / CH₂Cl₂ / 0 °C

7.1: NaI / acetone / Heating

8.1: BuLi / tetrahydrofuran / -78 - 20 °C

8.2: tetrahydrofuran / -78 - 20 °C

9.1: (+/-)-CSA / methanol; H₂O / 60 °C

10.1: 72 percent / diethyl ether / -78 °C

11.1: aq. AcOH / 60 °C

12.1: 1,2-dichloro-ethane / 80 °C

13.1: 68 percent / Et₃N; DMAP / dimethylformamide / 40 °C

14.1: 87 percent / PDC; 4 Angstroem molecular sieves / CH₂Cl₂ / 20 °C

15.1: 81 percent / NaBH₄ / methanol / 0 °C

16.1: CBr₄; Ph₃P / CH₂Cl₂ / 20 °C

17.1: 55 percent / SmI₂ / tetrahydrofuran; hexamethylphosphoric acid triamide / 20 °C

18.1: 78 percent / DIBALH / diethyl ether / -78 °C

19.1: Bu₃P; pyridine / 20 °C

20.1: MCPBA / CH₂Cl₂

21.1: i-Pr₂NEt / 1,2-dichloro-benzene / 160 °C

22.1: 95 percent / Na; NH₃ / tetrahydrofuran / -78 °C

With pyridine; dmap; sodium tetrahydroborate; lithium aluminium tetrahydride; dipyridinium dichromate; n-butyllithium; samarium diiodide; carbon tetrabromide; tributylphosphine; 4 A molecular sieve; 10-camphorsufonic acid; tetrabutyl ammonium fluoride; ammonia; sodium; sodium hydride; diisobutylaluminium hydride; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; sodium iodide; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; 1,2-dichloro-benzene; acetone; 12.1: Wittig reaction;