(2R,5S)-N-benzyl-2-(acetoxymethyl)-5-(hydroxymethyl)-2,5-dihydropyrrole

Base Information

Chemical Name:(2R,5S)-N-benzyl-2-(acetoxymethyl)-5-(hydroxymethyl)-2,5-dihydropyrrole
CAS No.:1453193-38-8
Molecular Formula:C₁₅H₁₉NO₃
Molecular Weight:261.321
Hs Code.:

Synonyms:(2R,5S)-N-benzyl-2-(acetoxymethyl)-5-(hydroxymethyl)-2,5-dihydropyrrole

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Chemical Property of (2R,5S)-N-benzyl-2-(acetoxymethyl)-5-(hydroxymethyl)-2,5-dihydropyrrole

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Technology Process of (2R,5S)-N-benzyl-2-(acetoxymethyl)-5-(hydroxymethyl)-2,5-dihydropyrrole

There total 2 articles about (2R,5S)-N-benzyl-2-(acetoxymethyl)-5-(hydroxymethyl)-2,5-dihydropyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 108-05-4,9003-20-7
vinyl acetate

: 1208240-11-2
(1-benzyl-2,5-dihydro-1H-pyrrole-2,5-diyl)dimethanol

: C₁₇H₂₁NO₄

: 1453193-38-8
(2R,5S)-N-benzyl-2-(acetoxymethyl)-5-(hydroxymethyl)-2,5-dihydropyrrole

Guidance literature:: With lipase from Mucor miehei; In toluene; at 22 ℃; for 16h; enantioselective reaction; Enzymatic reaction;
DOI:10.1055/s-0033-1338960

Reference yield:

: 108-05-4,9003-20-7
vinyl acetate

: 1208240-11-2
(1-benzyl-2,5-dihydro-1H-pyrrole-2,5-diyl)dimethanol

: 1453193-38-8
(2R,5S)-N-benzyl-2-(acetoxymethyl)-5-(hydroxymethyl)-2,5-dihydropyrrole

: (2R,5S)-N-benzyl-2-(acetoxymethyl)-5-(hydroxymethyl)-2,5-dihydropyrrole

Guidance literature:: With lipase from Pseudomonas fluorescens; In toluene; at 35 ℃; for 16h; Overall yield = 56 %; enantioselective reaction; Enzymatic reaction;
DOI:10.1055/s-0033-1338960

Reference yield: 45.0%

: 1453193-38-8
(2R,5S)-N-benzyl-2-(acetoxymethyl)-5-(hydroxymethyl)-2,5-dihydropyrrole

: 1453193-43-5
(3R,6R)-N-benzyl-6-(acetoxymethyl)-3-acetoxy-1,2,3,6-tetrahydropyridine

: C₁₇H₂₁NO₄

Guidance literature:: (2R,5S)-N-benzyl-2-(acetoxymethyl)-5-(hydroxymethyl)-2,5-dihydropyrrole; With N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; In dichloromethane; at -20 ℃; for 0.5h;

With trifluoromethylsulfonic anhydride; In dichloromethane; at -20 ℃; for 0.5h;

With sodium acetate; In dichloromethane; at -20 ℃;
DOI:10.1055/s-0033-1338960