(Z)-ethyl 2-((4-benzhydrylpiperazin-1-yl)methyl)-3-(4-fluorophenyl)acrylate

Base Information

Chemical Name:(Z)-ethyl 2-((4-benzhydrylpiperazin-1-yl)methyl)-3-(4-fluorophenyl)acrylate
CAS No.:1527470-76-3
Molecular Formula:C₂₉H₃₁FN₂O₂
Molecular Weight:458.576
Hs Code.:

Synonyms:(Z)-ethyl 2-((4-benzhydrylpiperazin-1-yl)methyl)-3-(4-fluorophenyl)acrylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (Z)-ethyl 2-((4-benzhydrylpiperazin-1-yl)methyl)-3-(4-fluorophenyl)acrylate

Chemical Property:

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Technology Process of (Z)-ethyl 2-((4-benzhydrylpiperazin-1-yl)methyl)-3-(4-fluorophenyl)acrylate

There total 7 articles about (Z)-ethyl 2-((4-benzhydrylpiperazin-1-yl)methyl)-3-(4-fluorophenyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 841-77-0
diphenylmethylpiperazine

: 134294-35-2
(Z)-2-Bromomethyl-3-(4-fluoro-phenyl)-acrylic acid ethyl ester

: 1527470-76-3
(Z)-ethyl 2-((4-benzhydrylpiperazin-1-yl)methyl)-3-(4-fluorophenyl)acrylate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 6h;
DOI:10.1007/s00044-013-0895-7

Reference yield:

: 652980-11-5
ethyl 2-((4-fluorophenyl)(hydroxy)methyl)acrylate

: 1527470-76-3
(Z)-ethyl 2-((4-benzhydrylpiperazin-1-yl)methyl)-3-(4-fluorophenyl)acrylate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen bromide; sulfuric acid / dichloromethane / 0 - 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 6 h / 20 °C

With sulfuric acid; hydrogen bromide; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1007/s00044-013-0895-7

Reference yield:

: 459-57-4
4-fluorobenzaldehyde

: 1527470-76-3
(Z)-ethyl 2-((4-benzhydrylpiperazin-1-yl)methyl)-3-(4-fluorophenyl)acrylate

Guidance literature:: Multi-step reaction with 3 steps

1: 1,4-diaza-bicyclo[2.2.2]octane / neat (no solvent) / 20 °C

2: hydrogen bromide; sulfuric acid / dichloromethane / 0 - 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 6 h / 20 °C

With 1,4-diaza-bicyclo[2.2.2]octane; sulfuric acid; hydrogen bromide; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1007/s00044-013-0895-7