2-isocyano-5-methoxy-1-tetrahydrofuranyloxybenzene

Base Information

• Chemical Name: 2-isocyano-5-methoxy-1-tetrahydrofuranyloxybenzene
• CAS No.: 1355021-23-6
• Molecular Formula: C₁₂H₁₃NO₃
• Molecular Weight: 219.24
• Mol file: 1355021-23-6.mol

Synonyms:2-isocyano-5-methoxy-1-tetrahydrofuranyloxybenzene

Chemical Property of 2-isocyano-5-methoxy-1-tetrahydrofuranyloxybenzene

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 2-isocyano-5-methoxy-1-tetrahydrofuranyloxybenzene

There total 3 articles about 2-isocyano-5-methoxy-1-tetrahydrofuranyloxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(4-methoxy-2-(2-tetrahydrofuranyloxy)phenyl)formamide (1355021-67-8) → 2-isocyano-5-methoxy-1-tetrahydrofuranyloxybenzene (1355021-23-6)

Guidance literature:

With triethylamine; trichlorophosphate; In tetrahydrofuran; at 0 ℃; for 1h; Inert atmosphere;

DOI:10.1021/ol203175a

Reference yield:

2-amino-5-methoxyphenol (40925-70-0) → 2-isocyano-5-methoxy-1-tetrahydrofuranyloxybenzene (1355021-23-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 0.5 h / 110 °C / Inert atmosphere; Microwave irradiation

2: pyridinium p-toluenesulfonate / 22 h / 20 °C / Inert atmosphere

3: triethylamine; trichlorophosphate / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

With pyridinium p-toluenesulfonate; triethylamine; trichlorophosphate; In tetrahydrofuran;

DOI:10.1021/ol203175a

Reference yield:

N-(2-hydroxy-4-methoxyphenyl)formamide → 2-isocyano-5-methoxy-1-tetrahydrofuranyloxybenzene (1355021-23-6)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridinium p-toluenesulfonate / 22 h / 20 °C / Inert atmosphere

2: triethylamine; trichlorophosphate / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

With pyridinium p-toluenesulfonate; triethylamine; trichlorophosphate; In tetrahydrofuran;

DOI:10.1021/ol203175a

upstream raw materials:

N-(4-methoxy-2-(2-tetrahydrofuranyloxy)phenyl)formamide

2-amino-5-methoxyphenol