Technology Process of (3aR,7S,7aR)-3a-methyl-3a,4,5,6,7,7a-hexahydro-1H-inden-7-ol benzoate
There total 10 articles about (3aR,7S,7aR)-3a-methyl-3a,4,5,6,7,7a-hexahydro-1H-inden-7-ol benzoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
formic acid; bis(acetato)bis(triphenylphosphine)palladium(0); tributyl-amine;
In
N,N-dimethyl-formamide;
at 20 - 60 ℃;
DOI:10.1021/jo201083w
- Guidance literature:
-
Multi-step reaction with 5 steps
1: pyridine; dmap / 1 h / Reflux
2: cerium(III) chloride heptahydrate; sodium iodide / acetonitrile / 2 h / Reflux
3: Jones reagent / acetone / 20 h
4: 2,6-di-tert-butyl-4-methylpyridine / dichloromethane / 6 h / 20 °C
5: bis(acetato)bis(triphenylphosphine)palladium(0); formic acid; tributyl-amine / N,N-dimethyl-formamide / 20 - 60 °C
With
pyridine; dmap; Jones reagent; formic acid; 2,6-di-tert-butyl-4-methylpyridine; bis(acetato)bis(triphenylphosphine)palladium(0); tributyl-amine; cerium(III) chloride heptahydrate; sodium iodide;
In
dichloromethane; N,N-dimethyl-formamide; acetone; acetonitrile;
DOI:10.1021/jo201083w
- Guidance literature:
-
Multi-step reaction with 9 steps
1: boron trifluoride diethyl etherate; sodium cyanoborohydride / diethyl ether / 2 h / 20 °C
2: tetrahydrofuran / 3 h / Reflux
3: copper; sodium hydrogencarbonate / 40 h / 45 °C / sealed ampule
4: lithium aluminium tetrahydride / tetrahydrofuran / 0.25 h / Reflux
5: pyridine; dmap / 1 h / Reflux
6: cerium(III) chloride heptahydrate; sodium iodide / acetonitrile / 2 h / Reflux
7: Jones reagent / acetone / 20 h
8: 2,6-di-tert-butyl-4-methylpyridine / dichloromethane / 6 h / 20 °C
9: bis(acetato)bis(triphenylphosphine)palladium(0); formic acid; tributyl-amine / N,N-dimethyl-formamide / 20 - 60 °C
With
pyridine; dmap; lithium aluminium tetrahydride; Jones reagent; formic acid; 2,6-di-tert-butyl-4-methylpyridine; bis(acetato)bis(triphenylphosphine)palladium(0); tributyl-amine; cerium(III) chloride heptahydrate; boron trifluoride diethyl etherate; copper; sodium cyanoborohydride; sodium hydrogencarbonate; sodium iodide;
In
tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; acetone; acetonitrile;
DOI:10.1021/jo201083w
